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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(EIF1AX-Il31ra)1Jagr
transgene insertion 1, Jane A Gross
MGI:3047472
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(EIF1AX-Il31ra)1Jagr/0 involves: C3H * C57BL/6 MGI:3047484


Genotype
MGI:3047484
tg1
Allelic
Composition
Tg(EIF1AX-Il31ra)1Jagr/0
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• excessive scratching resulting in abrasions and lesions
• at 4-8 weeks of age piloerection is seen

hearing/vestibular/ear
• by 2 months of age most transgenic mice develop epidermal thickening of ear pinnae resulting in ears up to 2.5 times thicker than wild-type

immune system
• at 6 months of age an increase in mast cell numbers is seen in the skin
• the overall proportion of B cells is increased resulting in an inverse ration of B to T cells compared to wild-type
• the proportion of activated and memory T cells in the total T cell population is increased compared to wild-type
• the overall proportion of T cells is decreased resulting in an inverse ratio of B to T cells compared to wild-type
• the proportion of activated and memory T cells in the total T cell population is increased compared to wild-type
• the peripheral lymph nodes are enlarged 2 - 5 fold compared to wild-type
• 67% of transgenic mice develop conjunctivitis with swelling around the eye
• inflammatory cell infiltration and other features of the skin lesions resemble dermatitis

hematopoietic system
• at 6 months of age an increase in mast cell numbers is seen in the skin
• the overall proportion of B cells is increased resulting in an inverse ration of B to T cells compared to wild-type
• the proportion of activated and memory T cells in the total T cell population is increased compared to wild-type
• the overall proportion of T cells is decreased resulting in an inverse ratio of B to T cells compared to wild-type
• the proportion of activated and memory T cells in the total T cell population is increased compared to wild-type

vision/eye
• 67% of transgenic mice develop conjunctivitis with swelling around the eye

craniofacial
• by 2 months of age most transgenic mice develop epidermal thickening of ear pinnae resulting in ears up to 2.5 times thicker than wild-type

integument
• inflammatory cell infiltration and other features of the skin lesions resemble dermatitis
• at 8 weeks alopecia is seen in greater than 25% of transgenic mice and by 6 months 80-100% had moderate to severe hair loss
• hyperkeratosis is seen particularly in lesional skin
• at 6 months acanthosis is seen particularly in lesional skin

growth/size/body
• by 2 months of age most transgenic mice develop epidermal thickening of ear pinnae resulting in ears up to 2.5 times thicker than wild-type





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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory