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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd79atm4Cgn
targeted mutation 4, University of Cologne
MGI:3047536
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd79atm4Cgn/Cd79atm4.1Cgn
Tg(Cr2-cre)3Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3047600
cn2
 		Cd79atm4Cgn/Cd79atm4.1Cgn
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3047599


Genotype
MGI:3047600
cn1
Allelic
Composition		 Cd79atm4Cgn/Cd79atm4.1Cgn
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm4.1Cgn mutation (1 available); any Cd79a mutation (24 available)
Cd79atm4Cgn mutation (0 available); any Cd79a mutation (24 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:91091 )
• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes
• B cell half life is about 3 - 6 days
decreased IgD level ( J:91091 )
• B cell surface IgD levels are decreased about 100 fold on around 1/3 and 1/2 of spleen or inguinal lymph node B cells, respectively
decreased IgM level ( J:91091 )
• B cell surface IgM levels are decreased about 30 fold on around 1/3 and 1/2 of spleen or inguinal lymph node B cells, respectively

immune system
decreased B cell number ( J:91091 )
• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes
• B cell half life is about 3 - 6 days
decreased IgD level ( J:91091 )
• B cell surface IgD levels are decreased about 100 fold on around 1/3 and 1/2 of spleen or inguinal lymph node B cells, respectively
decreased IgM level ( J:91091 )
• B cell surface IgM levels are decreased about 30 fold on around 1/3 and 1/2 of spleen or inguinal lymph node B cells, respectively




Genotype
MGI:3047599
cn2
Allelic
Composition		 Cd79atm4Cgn/Cd79atm4.1Cgn
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm4.1Cgn mutation (1 available); any Cd79a mutation (24 available)
Cd79atm4Cgn mutation (0 available); any Cd79a mutation (24 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:91091 )
• 2 weeks after p(I)p(C) injections an almost complete block in B cell development is seen
decreased B cell number ( J:91091 )
• 2 weeks after p(I)p(C) injections two thirds of the B cells are lost from the spleen, blood, lymph nodes, liver, and lung
• mature follicular B cells are more affected than marginal zone B cells
absent immature B cells ( J:91091 )
• in the spleen almost all immature spleen cells are missing

immune system
arrested B cell differentiation ( J:91091 )
• 2 weeks after p(I)p(C) injections an almost complete block in B cell development is seen
decreased B cell number ( J:91091 )
• 2 weeks after p(I)p(C) injections two thirds of the B cells are lost from the spleen, blood, lymph nodes, liver, and lung
• mature follicular B cells are more affected than marginal zone B cells
absent immature B cells ( J:91091 )
• in the spleen almost all immature spleen cells are missing




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory