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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd79atm5Cgn
targeted mutation 5, University of Cologne
MGI:3047538
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd79atm5Cgn/Cd79atm5.1Cgn
Tg(Cr2-cre)3Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3047604
cn2
 		Cd79atm5Cgn/Cd79atm5.1Cgn
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3047603


Genotype
MGI:3047604
cn1
Allelic
Composition		 Cd79atm5Cgn/Cd79atm5.1Cgn
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm5.1Cgn mutation (0 available); any Cd79a mutation (24 available)
Cd79atm5Cgn mutation (0 available); any Cd79a mutation (24 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:91091 )
• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes

immune system
decreased B cell number ( J:91091 )
• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes




Genotype
MGI:3047603
cn2
Allelic
Composition		 Cd79atm5Cgn/Cd79atm5.1Cgn
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm5.1Cgn mutation (0 available); any Cd79a mutation (24 available)
Cd79atm5Cgn mutation (0 available); any Cd79a mutation (24 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:91091 )
• about 2 weeks after p(I)p(C) injections an almost complete block in B cell development is seen
decreased B cell number ( J:91091 )
• about 2 weeks after p(I)p(C) injections most of the B cells are lost from the spleen and lymph nodes
• marginal zone B cells were not affected probably as a result of replenishment from cells that escaped cre mediated recombination
absent immature B cells ( J:91091 )
• in the spleen almost all immature spleen cells are missing

immune system
arrested B cell differentiation ( J:91091 )
• about 2 weeks after p(I)p(C) injections an almost complete block in B cell development is seen
decreased B cell number ( J:91091 )
• about 2 weeks after p(I)p(C) injections most of the B cells are lost from the spleen and lymph nodes
• marginal zone B cells were not affected probably as a result of replenishment from cells that escaped cre mediated recombination
absent immature B cells ( J:91091 )
• in the spleen almost all immature spleen cells are missing




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory