About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd79atm5Cgn
targeted mutation 5, University of Cologne
MGI:3047538
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd79atm5Cgn/Cd79atm5.1Cgn
Tg(Cr2-cre)3Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3047604
cn2
 		Cd79atm5Cgn/Cd79atm5.1Cgn
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:3047603


Genotype
MGI:3047604
cn1
Allelic
Composition		 Cd79atm5Cgn/Cd79atm5.1Cgn
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm5.1Cgn mutation (0 available); any Cd79a mutation (24 available)
Cd79atm5Cgn mutation (0 available); any Cd79a mutation (24 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased B cell number ( J:91091 )
• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes

immune system
decreased B cell number ( J:91091 )
• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes




Genotype
MGI:3047603
cn2
Allelic
Composition		 Cd79atm5Cgn/Cd79atm5.1Cgn
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm5.1Cgn mutation (0 available); any Cd79a mutation (24 available)
Cd79atm5Cgn mutation (0 available); any Cd79a mutation (24 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
arrested B cell differentiation ( J:91091 )
• about 2 weeks after p(I)p(C) injections an almost complete block in B cell development is seen
decreased B cell number ( J:91091 )
• about 2 weeks after p(I)p(C) injections most of the B cells are lost from the spleen and lymph nodes
• marginal zone B cells were not affected probably as a result of replenishment from cells that escaped cre mediated recombination
absent immature B cells ( J:91091 )
• in the spleen almost all immature spleen cells are missing

immune system
arrested B cell differentiation ( J:91091 )
• about 2 weeks after p(I)p(C) injections an almost complete block in B cell development is seen
decreased B cell number ( J:91091 )
• about 2 weeks after p(I)p(C) injections most of the B cells are lost from the spleen and lymph nodes
• marginal zone B cells were not affected probably as a result of replenishment from cells that escaped cre mediated recombination
absent immature B cells ( J:91091 )
• in the spleen almost all immature spleen cells are missing




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory