All Phenotypes Cd79a<tm5.1Cgn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd79a^tm5.1Cgn
targeted mutation 5.1, University of Cologne
MGI:3047539

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn	involves: 129 * C57BL/6	MGI:3760851
hm2	Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn	involves: 129P2/OlaHsd * C57BL/6	MGI:3047598
cn3	Cd79a^tm5Cgn/Cd79a^tm5.1Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3047604
cn4	Cd79a^tm5Cgn/Cd79a^tm5.1Cgn Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3047603
cx5	Cd79a^tm5.1Cgn/Cd79a⁺ Igh^tm1.2Rsky/Igh⁺	involves: 129 * BALB/c * C57BL/6	MGI:3760853
cx6	Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Igh^tm1.2Rsky/Igh⁺	involves: 129 * BALB/c * C57BL/6	MGI:3760854
cx7	Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Igh^tm1.2Rsky/Igh^tm1.2Rsky	involves: 129 * BALB/c * C57BL/6	MGI:3760855

Allelic Composition	Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm5.1Cgn mutation (0 available); any Cd79a mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell number ( J:125719 )

• 2 fold decrease in the number of T cells in the spleen

abnormal B cell morphology ( J:125719 )

decreased immature B cell number ( J:125719 )

• less than 1 percent of bone marrow cells are immature B cells ( normal is about 8%)

increased pro-B cell number ( J:125719 )

• about 2 fold increase due to block in development from pro-B cell to pre-B cell

decreased mature B cell number ( J:125719 )

• 100 fold decrease in the number of B cells in the spleen

• 20 fold decrease in the number of B cells in the peritoneal cavity

decreased B-1a cell number ( J:125719 )

• 3 fold decrease in the peritoneal cavity

decreased pre-B cell number ( J:125719 )

• very few pre-B cells exist in the bone marrow

hematopoietic system

decreased T cell number ( J:125719 )

• 2 fold decrease in the number of T cells in the spleen

abnormal B cell morphology ( J:125719 )

decreased immature B cell number ( J:125719 )

• less than 1 percent of bone marrow cells are immature B cells ( normal is about 8%)

increased pro-B cell number ( J:125719 )

• about 2 fold increase due to block in development from pro-B cell to pre-B cell

decreased mature B cell number ( J:125719 )

• 100 fold decrease in the number of B cells in the spleen

• 20 fold decrease in the number of B cells in the peritoneal cavity

decreased B-1a cell number ( J:125719 )

• 3 fold decrease in the peritoneal cavity

decreased pre-B cell number ( J:125719 )

• very few pre-B cells exist in the bone marrow

Allelic Composition	Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm5.1Cgn mutation (0 available); any Cd79a mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:91091 )

• B cell development is severely impaired

immune system

abnormal B cell differentiation ( J:91091 )

• B cell development is severely impaired

Allelic Composition	Cd79a^tm5Cgn/Cd79a^tm5.1Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm5.1Cgn mutation (0 available); any Cd79a mutation (24 available)
Cd79a^tm5Cgn mutation (0 available); any Cd79a mutation (24 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B cell number ( J:91091 )

• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes

immune system

decreased B cell number ( J:91091 )

• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes

Allelic Composition	Cd79a^tm5Cgn/Cd79a^tm5.1Cgn Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

arrested B cell differentiation ( J:91091 )

• about 2 weeks after p(I)p(C) injections an almost complete block in B cell development is seen

decreased B cell number ( J:91091 )

• about 2 weeks after p(I)p(C) injections most of the B cells are lost from the spleen and lymph nodes

• marginal zone B cells were not affected probably as a result of replenishment from cells that escaped cre mediated recombination

absent immature B cells ( J:91091 )

• in the spleen almost all immature spleen cells are missing

immune system

arrested B cell differentiation ( J:91091 )

• about 2 weeks after p(I)p(C) injections an almost complete block in B cell development is seen

decreased B cell number ( J:91091 )

• about 2 weeks after p(I)p(C) injections most of the B cells are lost from the spleen and lymph nodes

• marginal zone B cells were not affected probably as a result of replenishment from cells that escaped cre mediated recombination

absent immature B cells ( J:91091 )

• in the spleen almost all immature spleen cells are missing

Allelic Composition	Cd79a^tm5.1Cgn/Cd79a⁺ Igh^tm1.2Rsky/Igh⁺
Genetic Background	involves: 129 * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm5.1Cgn mutation (0 available); any Cd79a mutation (24 available)
Igh^tm1.2Rsky mutation (0 available); any Igh mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal class switch recombination ( J:125719 )

• slight increase in the percentage of B cells expressing IgG1

immune system

abnormal class switch recombination ( J:125719 )

• slight increase in the percentage of B cells expressing IgG1

Allelic Composition	Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Igh^tm1.2Rsky/Igh⁺
Genetic Background	involves: 129 * BALB/c * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal class switch recombination ( J:125719 )

• increased percentage of B cells expressing IgG1 in the bone marrow and spleen compared to mutant mice with a wild-type Igalpha allele

immune system

abnormal class switch recombination ( J:125719 )

• increased percentage of B cells expressing IgG1 in the bone marrow and spleen compared to mutant mice with a wild-type Igalpha allele

Allelic Composition	Cd79a^tm5.1Cgn/Cd79a^tm5.1Cgn Igh^tm1.2Rsky/Igh^tm1.2Rsky
Genetic Background	involves: 129 * BALB/c * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell number ( J:125719 )

• 2 fold decrease in the number of T cells in the spleen

abnormal B cell morphology ( J:125719 )

abnormal class switch recombination ( J:125719 )

• more than a five fold increase in the percentage of B cells expressing IgG1

decreased immature B cell number ( J:125719 )

• less than 1 percent of bone marrow cells are immature B cells ( normal is about 8%)

increased pro-B cell number ( J:125719 )

• about 2 fold increase due to block in development from pro-B cell to pre-B cell

decreased mature B cell number ( J:125719 )

• 10 fold decrease in the number of B cells in the spleen

• 6 fold decrease in the number of B cells in the peritoneal cavity

• these numbers are higher than mice that are only null for Igalpha expression

increased B-1b cell number ( J:125719 )

• increased both in the spleen and peritoneal cavity

decreased pre-B cell number ( J:125719 )

• very few pre-B cells exist in the bone marrow

hematopoietic system

decreased T cell number ( J:125719 )

• 2 fold decrease in the number of T cells in the spleen

abnormal B cell morphology ( J:125719 )

abnormal class switch recombination ( J:125719 )

• more than a five fold increase in the percentage of B cells expressing IgG1

decreased immature B cell number ( J:125719 )

• less than 1 percent of bone marrow cells are immature B cells ( normal is about 8%)

increased pro-B cell number ( J:125719 )

• about 2 fold increase due to block in development from pro-B cell to pre-B cell

decreased mature B cell number ( J:125719 )

• 10 fold decrease in the number of B cells in the spleen

• 6 fold decrease in the number of B cells in the peritoneal cavity

• these numbers are higher than mice that are only null for Igalpha expression

increased B-1b cell number ( J:125719 )

• increased both in the spleen and peritoneal cavity

decreased pre-B cell number ( J:125719 )

• very few pre-B cells exist in the bone marrow

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