Phenotypes associated with this allele

• Allele Symbol: Bach2^tm1Igar
• Allele Name: targeted mutation 1, Kazuhiko Igarashi
• Allele ID: MGI:3047541
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bach2^tm1Igar/Bach2^tm1Igar	involves: 129P2/OlaHsd * C57BL/6J	MGI:3047667

Genotype
MGI:3047667

hm1

• Allelic Composition: Bach2^tm1Igar/Bach2^tm1Igar
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal B cell differentiation ( J:91110 )

• B cell differentiation in the marginal and follicular zones of the spleen is impaired

abnormal somatic hypermutation frequency ( J:91110 )

• impaired

decreased B cell number ( J:91110 )

• the number of B220^high IgM⁺ B cells in the bone marrow is less than 40% of wild-type littermates

decreased mature B cell number ( J:91110 )

• the number of mature B cells but not nave B cells is decreased in the spleen

absent germinal center B cells ( J:91110 )

• germinal center B cell are absent

spleen hypoplasia ( J:91110 )

• the total number of cells in the spleen is decreased

abnormal B cell physiology ( J:91110 )

abnormal class switch recombination ( J:91110 )

• impaired

decreased IgA level ( J:91110 )

• IgA mean concentration is decreased to 25% of wild-type

decreased IgG level ( J:91110 )

• IgG1, IgG2a, IgG2b, and IgG3 mean concentrations are decreased to 31%, 5%, 33%, and 4% of wild-type, respectively

• mutants fail to increase IgG1, IgG3 in response to antigen stimulation

decreased IgG1 level ( J:91110 )

decreased IgG2a level ( J:91110 )

decreased IgG2b level ( J:91110 )

decreased IgG3 level ( J:91110 )

increased IgM level ( J:91110 )

• IgM levels are increased 5 fold in mutants

immune system

abnormal B cell differentiation ( J:91110 )

• B cell differentiation in the marginal and follicular zones of the spleen is impaired

abnormal somatic hypermutation frequency ( J:91110 )

• impaired

decreased B cell number ( J:91110 )

• the number of B220^high IgM⁺ B cells in the bone marrow is less than 40% of wild-type littermates

decreased mature B cell number ( J:91110 )

• the number of mature B cells but not nave B cells is decreased in the spleen

absent germinal center B cells ( J:91110 )

• germinal center B cell are absent

spleen hypoplasia ( J:91110 )

• the total number of cells in the spleen is decreased

abnormal B cell physiology ( J:91110 )

abnormal class switch recombination ( J:91110 )

• impaired

decreased IgA level ( J:91110 )

• IgA mean concentration is decreased to 25% of wild-type

decreased IgG level ( J:91110 )

• IgG1, IgG2a, IgG2b, and IgG3 mean concentrations are decreased to 31%, 5%, 33%, and 4% of wild-type, respectively

• mutants fail to increase IgG1, IgG3 in response to antigen stimulation

decreased IgG1 level ( J:91110 )

decreased IgG2a level ( J:91110 )

decreased IgG2b level ( J:91110 )

decreased IgG3 level ( J:91110 )

increased IgM level ( J:91110 )

• IgM levels are increased 5 fold in mutants