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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dnmt3atm3.1Enl
targeted mutation 3.1, En Li
MGI:3047552
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Alpltm1(cre)Nagy/Alpl+
Dnmt3atm3.1Enl/Dnmt3atm3.2Enl
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ MGI:3047840


Genotype
MGI:3047840
cn1
Allelic
Composition
Alpltm1(cre)Nagy/Alpl+
Dnmt3atm3.1Enl/Dnmt3atm3.2Enl
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpltm1(cre)Nagy mutation (6 available); any Alpl mutation (352 available)
Dnmt3atm3.1Enl mutation (2 available); any Dnmt3a mutation (139 available)
Dnmt3atm3.2Enl mutation (0 available); any Dnmt3a mutation (139 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• testes weight is greatly reduced at 11 weeks of age

reproductive system
• at P11 the number of spermatogonia are reduced and by 11 weeks of age few spermatogonia and no spermatocytes, spermatids, or spermatozoa are seen
• testes weight is greatly reduced at 11 weeks of age
• all embryos die around E10.5 with open neural tubes, absent branchial arches and pale skin
• this is a maternal effect mutation resulting from impaired maternal imprinting
• no pregnancies result from crossing mutant males with wild-type females

cellular
• at P11 the number of spermatogonia are reduced and by 11 weeks of age few spermatogonia and no spermatocytes, spermatids, or spermatozoa are seen





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory