endocrine/exocrine glands
• testes weight is greatly reduced at 11 weeks of age
|
reproductive system
azoospermia
(
J:91108
)
• at P11 the number of spermatogonia are reduced and by 11 weeks of age few spermatogonia and no spermatocytes, spermatids, or spermatozoa are seen
|
• testes weight is greatly reduced at 11 weeks of age
|
• all embryos die around E10.5 with open neural tubes, absent branchial arches and pale skin
• this is a maternal effect mutation resulting from impaired maternal imprinting
|
• no pregnancies result from crossing mutant males with wild-type females
|
cellular
azoospermia
(
J:91108
)
• at P11 the number of spermatogonia are reduced and by 11 weeks of age few spermatogonia and no spermatocytes, spermatids, or spermatozoa are seen
|