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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Prndtm1Aag
targeted mutation 1, Adriano Aguzzi
MGI:3047561
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Prndtm1Aag/Prndtm1Aag involves: 129P2/OlaHsd MGI:3047562


Genotype
MGI:3047562
hm1
Allelic
Composition		 Prndtm1Aag/Prndtm1Aag
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prndtm1Aag mutation (1 available); any Prnd mutation (8 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
oligozoospermia ( J:91621 )
• the number of spermatozoa in the cauda epididymis is reduced about 50%
teratozoospermia ( J:91621 )
• abnormal flagella and sperm heads are seen
hairpin sperm flagellum ( J:91621 )
• the mutant sperm flagellum is often folded back towards the sperm head instead of being straight and elongated
• however, the composition of the mitochondrial sheath appears unaffected
abnormal sperm head morphology ( J:91621 )
• mutant sperm heads are severely malformed and abnormally oriented with respect to the flagellum
abnormal acrosome morphology ( J:91621 )
• mutant sperm heads lack a discernible well-developed acrosome
asthenozoospermia ( J:91621 )
• sperm motility is significantly decreased
abnormal spermiogenesis ( J:91621 )
• transformation of round spermatids into spermatozoa is abnormal
• regional separation of differentiation stages is disturbed
male infertility ( J:91621 )
• male, but not female, mutants are infertile
impaired sperm penetration of zona pellucida ( J:91621 )
• sperm are unable to penetrate the zona pellucida

cellular
oligozoospermia ( J:91621 )
• the number of spermatozoa in the cauda epididymis is reduced about 50%
teratozoospermia ( J:91621 )
• abnormal flagella and sperm heads are seen
hairpin sperm flagellum ( J:91621 )
• the mutant sperm flagellum is often folded back towards the sperm head instead of being straight and elongated
• however, the composition of the mitochondrial sheath appears unaffected
abnormal sperm head morphology ( J:91621 )
• mutant sperm heads are severely malformed and abnormally oriented with respect to the flagellum
abnormal acrosome morphology ( J:91621 )
• mutant sperm heads lack a discernible well-developed acrosome
asthenozoospermia ( J:91621 )
• sperm motility is significantly decreased




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory