All Phenotypes Tg(Cr2-cre)3Cgn MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Cr2-cre)3Cgn
transgene insertion 3, University of Cologne
MGI:3047571

Summary

28 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nr4a1^tm1Pcn/Nr4a1^tm1Pcn Tg(Cr2-cre)3Cgn/0	involves: 129	MGI:6717462
cn2	Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd	MGI:4430560
cn3	Syk^tm1.2Tara/Syk^tm1.2Tara Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd	MGI:5568508
cn4	Foxo1^tm1.1Rdp/Foxo1⁺ Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * 129S1/Sv	MGI:4430558
cn5	Foxo1^tm1Rdp/Foxo1^tm1.1Rdp Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * 129S1/Sv	MGI:4430557
cn6	Tg(Cr2-cre)3Cgn/? Xrcc4^tm1Fwa/Xrcc4^tm2Fwa	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:4352685
cn7	Rag2^tm1Cgn/Rag2^tm1Cgn Xrcc4^tm1Fwa/Xrcc4^tm2Fwa Tg(Cr2-cre)3Cgn/?	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:4352688
cn8	Aicda^tm1Hon/Aicda^tm1Hon Tg(Cr2-cre)3Cgn/? Xrcc4^tm1Fwa/Xrcc4^tm2Fwa	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA	MGI:4352686
cn9	Tnfrsf1a^tm1Blt/Tnfrsf1a^tm2Gkl Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * 129S/SvEv	MGI:3687172
cn10	Cd79a^tm4Cgn/Cd79a^tm4.1Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3047600
cn11	Cd79a^tm5Cgn/Cd79a^tm5.1Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3047604
cn12	Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * C57BL/6	MGI:4430555
cn13	Gt(ROSA)26Sor^{tm8(Map2k1,EGFP)Rsky}/Gt(ROSA)26Sor^{tm8(Map2k1,EGFP)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * C57BL/6	MGI:4430561
cn14	Gt(ROSA)26Sor^{tm9(Rac1,EGFP)Rsky}/Gt(ROSA)26Sor^{tm9(Rac1,EGFP)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * C57BL/6	MGI:4430563
cn15	Cd40^tm1Kik/Cd40⁺ Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * C57BL/6	MGI:6360064
cn16	Dclre1c^tm2.1Jpdv/Dclre1c^tm2.2Jpdv Tg(Cr2-cre)3Cgn/0	involves: 129S2/SvPas * C57BL/6	MGI:4366790
cn17	Pten^tm1Hwu/Pten^tm1Hwu Tg(Cr2-cre)3Cgn/0	involves: 129S4/SvJae	MGI:4430559
cn18	Lig4^tm1Fwa/Lig4^tm1Fwa Tg(Cr2-cre)3Cgn/0 Xrcc4^tm2Fwa/Xrcc4^tm2Fwa	involves: 129S6/SvEvTac	MGI:4437909
cn19	Prkar1a^tm2Gsm/Prkar1a^tm2Gsm Tg(Cr2-cre)3Cgn/0	involves: 129X1/SvJ * C57BL/6	MGI:3845353
cn20	Gt(ROSA)26Sor^{tm2(Lmp1/CD40)Uzs}/Gt(ROSA)26Sor⁺ Tg(Cr2-cre)3Cgn/0	involves: BALB/c * C57BL/6	MGI:5567930
cn21	Mef2b^tm2Rdf/Mef2b⁺ Tg(BCL2/IGH)M23Tjd/0 Tg(Cr2-cre)3Cgn/0	involves: C3H/He * C57BL/6	MGI:6401158
cn22	Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Tg(Cr2-cre)3Cgn/0	involves: C57BL/6	MGI:6360060
cn23	Mef2b^tm2Rdf/Mef2b⁺ Tg(Cr2-cre)3Cgn/0	involves: C57BL/6	MGI:6401150
cn24	Rev3l^tm1Rsky/Rev3l^tm1.1Rsky Tg(Cr2-cre)3Cgn/?	involves: C57BL/6	MGI:3837750
cn25	Gt(ROSA)26Sor^{tm7(Pik3ca,EGFP)Rsky}/Gt(ROSA)26Sor^{tm7(Pik3ca,EGFP)Rsky} Tg(Cr2-cre)3Cgn/0	involves: C57BL/6	MGI:4430556
cn26	Ebf1^tm1.1Rug/Ebf1^tm1.1Rug Tg(Cr2-cre)3Cgn/0	involves: C57BL/6 * SJL	MGI:5316374
cn27	Lig4^tm3.1Fwa/Lig4^tm3.1Fwa Tg(Cr2-cre)3Cgn/0	Not Specified	MGI:4437901
cn28	Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	Not Specified	MGI:3576498

Allelic Composition	Nr4a1^tm1Pcn/Nr4a1^tm1Pcn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a1^tm1Pcn mutation (0 available); any Nr4a1 mutation (39 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased B cell proliferation ( J:306652 )

• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)

hematopoietic system

increased B cell proliferation ( J:306652 )

• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)

immune system

increased B cell proliferation ( J:306652 )

• greater proliferation of CD45.2+ B cells when co-cultured for 72 hours with congenically marked wild-type CD45.1+ lymphocytes and anti-immunoglobulin M (anti-IgM)

Allelic Composition	Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (13 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (44 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

hematopoietic system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

Allelic Composition	Syk^tm1.2Tara/Syk^tm1.2Tara Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syk^tm1.2Tara mutation (1 available); any Syk mutation (42 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal B cell morphology ( J:208904 )

• mature B cells exhibit a follicular B cell-like phenotype

immune system

abnormal B cell morphology ( J:208904 )

• mature B cells exhibit a follicular B cell-like phenotype

Allelic Composition	Foxo1^tm1.1Rdp/Foxo1⁺ Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1.1Rdp mutation (0 available); any Foxo1 mutation (32 available)
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (13 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (44 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell number ( J:157297 )

• mice exhibit a limited rescue of IgM negative B cells compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

hematopoietic system

increased B cell number ( J:157297 )

• mice exhibit a limited rescue of IgM negative B cells compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

Allelic Composition	Foxo1^tm1Rdp/Foxo1^tm1.1Rdp Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1.1Rdp mutation (0 available); any Foxo1 mutation (32 available)
Foxo1^tm1Rdp mutation (2 available); any Foxo1 mutation (32 available)
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (13 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (44 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

absent marginal zone B cells ( J:157297 )

increased B cell number ( J:157297 )

• mice exhibit an accumulation of IgM negative B cells compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

• mice exhibit an efficient rescue of BCR negative B cells compared with Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

• however, follicle B cells are rescued compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

hematopoietic system

absent marginal zone B cells ( J:157297 )

increased B cell number ( J:157297 )

• mice exhibit an accumulation of IgM negative B cells compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

• mice exhibit an efficient rescue of BCR negative B cells compared with Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

• however, follicle B cells are rescued compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

Allelic Composition	Tg(Cr2-cre)3Cgn/? Xrcc4^tm1Fwa/Xrcc4^tm2Fwa
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cr2-cre)3Cgn mutation (2 available)
Xrcc4^tm1Fwa mutation (0 available); any Xrcc4 mutation (26 available)
Xrcc4^tm2Fwa mutation (0 available); any Xrcc4 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

spontaneous chromosome breakage ( J:150339 )

• genomic stability is disrupted in activated B cells with chromosome breakage occurring in close to half of cells

• B cells undergoing class switch recombination have even greater increased risk of chromosome breakage due to aberrations at the Igh locus

• there is also increased breakage at the Igk and Igl loci with 1% of stimulated B cells demonstrating this

• Igl breaks in activated B cells are frequently fused to AID-dependent Igh breaks in the same cell to form chromosome 12/16 translocations

• there is also a five-fold increase in Igh-Myc translocations activated B cells compared to controls

hematopoietic system

abnormal class switch recombination ( J:150339 )

• class switch recombination often leads to chromosome breakage at the Igh locus

immune system

abnormal class switch recombination ( J:150339 )

• class switch recombination often leads to chromosome breakage at the Igh locus

Allelic Composition	Rag2^tm1Cgn/Rag2^tm1Cgn Xrcc4^tm1Fwa/Xrcc4^tm2Fwa Tg(Cr2-cre)3Cgn/?
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2^tm1Cgn mutation (2 available); any Rag2 mutation (119 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
Xrcc4^tm1Fwa mutation (0 available); any Xrcc4 mutation (26 available)
Xrcc4^tm2Fwa mutation (0 available); any Xrcc4 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

spontaneous chromosome breakage ( J:150339 )

• genomic stability is disrupted in activated B cells with chromosome breakage occurring in close to half of cells

• B cells undergoing class switch recombination have even greater increased risk of chromosome breakage due to aberrations at the Igh locus

• there is decreased breakage at Igl locus compared to conditional knockouts on a Rag-sufficient background

hematopoietic system

abnormal class switch recombination ( J:150339 )

• class switch recombination often leads to chromosome breakage at the Igh locus

immune system

abnormal class switch recombination ( J:150339 )

• class switch recombination often leads to chromosome breakage at the Igh locus

Allelic Composition	Aicda^tm1Hon/Aicda^tm1Hon Tg(Cr2-cre)3Cgn/? Xrcc4^tm1Fwa/Xrcc4^tm2Fwa
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1Hon mutation (7 available); any Aicda mutation (57 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
Xrcc4^tm1Fwa mutation (0 available); any Xrcc4 mutation (26 available)
Xrcc4^tm2Fwa mutation (0 available); any Xrcc4 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

spontaneous chromosome breakage ( J:150339 )

• genomic stability is disrupted in activated B cells with chromosome breakage occurring in close to half of cells

• however, there is no increased breakage of the Igh locus compared to wild-type controls

• there is increased breakage at the Igk and Igl loci with 1% of stimulated B cells demonstrating this

Allelic Composition	Tnfrsf1a^tm1Blt/Tnfrsf1a^tm2Gkl Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cr2-cre)3Cgn mutation (2 available)
Tnfrsf1a^tm1Blt mutation (6 available); any Tnfrsf1a mutation (52 available)
Tnfrsf1a^tm2Gkl mutation (1 available); any Tnfrsf1a mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:113314 )

N	• architecture of all secondary lymphoid organs is similar to wild-type

Allelic Composition	Cd79a^tm4Cgn/Cd79a^tm4.1Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm4.1Cgn mutation (1 available); any Cd79a mutation (24 available)
Cd79a^tm4Cgn mutation (0 available); any Cd79a mutation (24 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B cell number ( J:91091 )

• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes

• B cell half life is about 3 - 6 days

decreased IgD level ( J:91091 )

• B cell surface IgD levels are decreased about 100 fold on around 1/3 and 1/2 of spleen or inguinal lymph node B cells, respectively

decreased IgM level ( J:91091 )

• B cell surface IgM levels are decreased about 30 fold on around 1/3 and 1/2 of spleen or inguinal lymph node B cells, respectively

immune system

decreased B cell number ( J:91091 )

• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes

• B cell half life is about 3 - 6 days

decreased IgD level ( J:91091 )

• B cell surface IgD levels are decreased about 100 fold on around 1/3 and 1/2 of spleen or inguinal lymph node B cells, respectively

decreased IgM level ( J:91091 )

• B cell surface IgM levels are decreased about 30 fold on around 1/3 and 1/2 of spleen or inguinal lymph node B cells, respectively

Allelic Composition	Cd79a^tm5Cgn/Cd79a^tm5.1Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79a^tm5.1Cgn mutation (0 available); any Cd79a mutation (24 available)
Cd79a^tm5Cgn mutation (0 available); any Cd79a mutation (24 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B cell number ( J:91091 )

• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes

immune system

decreased B cell number ( J:91091 )

• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes

Allelic Composition	Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky} mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (13 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (44 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell number ( J:157297 )

• mice exhibit a very limited rescue of BCR negative B cells in several lymphoid organs compared with Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

hematopoietic system

increased B cell number ( J:157297 )

• mice exhibit a very limited rescue of BCR negative B cells in several lymphoid organs compared with Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

Allelic Composition	Gt(ROSA)26Sor^{tm8(Map2k1,EGFP)Rsky}/Gt(ROSA)26Sor^{tm8(Map2k1,EGFP)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm8(Map2k1*,EGFP)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (13 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (44 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

hematopoietic system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

Allelic Composition	Gt(ROSA)26Sor^{tm9(Rac1,EGFP)Rsky}/Gt(ROSA)26Sor^{tm9(Rac1,EGFP)Rsky} Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm9(Rac1*,EGFP)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (13 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (44 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

hematopoietic system

decreased mature B cell number ( J:157297 )

• mice lack mature BCR positive B cells

Allelic Composition	Cd40^tm1Kik/Cd40⁺ Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40^tm1Kik mutation (11 available); any Cd40 mutation (53 available)
Mir146^tm1.1Lfl mutation (1 available); any Mir146 mutation (9 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:266124 )

N	• mice exhibit a restoration of normal IgG1 levels in B cells compared with Mir146^tm1.1Tmmc Tg(Cr2-cre)3Cgn mice

increased T follicular helper cell number ( J:266124 )

• following immunization with sheep red blood cells in mixed bone marrow chimeras

hematopoietic system

increased T follicular helper cell number ( J:266124 )

• following immunization with sheep red blood cells in mixed bone marrow chimeras

Allelic Composition	Dclre1c^tm2.1Jpdv/Dclre1c^tm2.2Jpdv Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclre1c^tm2.1Jpdv mutation (1 available); any Dclre1c mutation (31 available)
Dclre1c^tm2.2Jpdv mutation (0 available); any Dclre1c mutation (31 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:153841 )

N	• mice exhibit normal B cell development and Ig titers

abnormal class switch recombination ( J:153841 )

• class switching to IgG3 is decreased 23% compared to in wild-type mice

• in vivo Ig switching to IgA on KLH immunization is reduced 52% compared to in similarly treated wild-type mice

• class switch recombination junctions are altered compared to in wild-type mice

hematopoietic system

abnormal class switch recombination ( J:153841 )

• class switching to IgG3 is decreased 23% compared to in wild-type mice

• in vivo Ig switching to IgA on KLH immunization is reduced 52% compared to in similarly treated wild-type mice

• class switch recombination junctions are altered compared to in wild-type mice

Allelic Composition	Pten^tm1Hwu/Pten^tm1Hwu Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:157297 )

• no time point given

Allelic Composition	Lig4^tm1Fwa/Lig4^tm1Fwa Tg(Cr2-cre)3Cgn/0 Xrcc4^tm2Fwa/Xrcc4^tm2Fwa
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm1Fwa mutation (2 available); any Lig4 mutation (46 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
Xrcc4^tm2Fwa mutation (0 available); any Xrcc4 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:126758 )

• class switching to IgG1 is 20% to 50% of wild-type

• class switching to IgG3 is 50% of wild-type

• IgH class switching is reduced compared to in wild-type B cells

cellular

increased cellular sensitivity to ionizing radiation ( J:126758 )

• in cultured B cells

spontaneous chromosome breakage ( J:126758 )

• B cell stimulated with anti-CD40 and IL4 exhibit metaphase chromosome breaks unlike similarly treated wild-type cells

hematopoietic system

abnormal class switch recombination ( J:126758 )

• class switching to IgG1 is 20% to 50% of wild-type

• class switching to IgG3 is 50% of wild-type

• IgH class switching is reduced compared to in wild-type B cells

Allelic Composition	Prkar1a^tm2Gsm/Prkar1a^tm2Gsm Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar1a^tm2Gsm mutation (1 available); any Prkar1a mutation (19 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:147785 )

• following stimulation with LPS and LPS plus IL4, splenic B cells exhibit impaired class switch recombination compared with wild-type cells

• however, stimulated B cell proliferation is normal

hematopoietic system

abnormal class switch recombination ( J:147785 )

• following stimulation with LPS and LPS plus IL4, splenic B cells exhibit impaired class switch recombination compared with wild-type cells

• however, stimulated B cell proliferation is normal

Allelic Composition	Gt(ROSA)26Sor^{tm2(Lmp1/CD40)Uzs}/Gt(ROSA)26Sor⁺ Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(Lmp1/CD40)Uzs} mutation (0 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal immune system morphology ( J:137122 )

• mice exhibit the same immune phenotype as in Gt(ROSA)26Sor^{tm2(Lmp1/CD40)Uzs} Cd19^tm1(cre)Cgn double heterozygotes

abnormal immune system physiology ( J:137122 )

• mice exhibit the same immune phenotype as in Gt(ROSA)26Sor^{tm2(Lmp1/CD40)Uzs} Cd19^tm1(cre)Cgn double heterozygotes

Allelic Composition	Mef2b^tm2Rdf/Mef2b⁺ Tg(BCL2/IGH)M23Tjd/0 Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: C3H/He * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2b^tm2Rdf mutation (0 available); any Mef2b mutation (22 available)
Tg(BCL2/IGH)M23Tjd mutation (0 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased lymphoma incidence ( J:265465 )

• plasmablastic lymphoma (PBL) in 20% of mice at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

increased follicular lymphoma incidence ( J:265465 )

• in 40% of mice at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

Allelic Composition	Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mir146^tm1.1Lfl mutation (1 available); any Mir146 mutation (9 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased germinal center B cell number ( J:266124 )

• minimal in young un-immunized mice on GL7+PNA+, which is further exacerbated with age

• at 6 months of age in un-immunized mice

• in young mice immunized with sheep red blood cells

increased plasma cell number ( J:266124 )

• in young mice immunized with sheep red blood cells

increased T follicular helper cell number ( J:266124 )

• at 6 months of age in un-immunized mice

• in young mice immunized with sheep red blood cells

increased IgG level ( J:266124 )

• SRBC-specific in young mice immunized with sheep red blood cells (SRBC)

increased IgG1 level ( J:266124 )

• following immunization with 4-hydroxy-3-nitrophenyl linked to Keyhole Limpet Hemocyanin (KLH) (NP-KLH) in alum

increased anti-double stranded DNA antibody level ( J:266124 )

• at 6 months of age in un-immunized mice

hematopoietic system

increased germinal center B cell number ( J:266124 )

• minimal in young un-immunized mice on GL7+PNA+, which is further exacerbated with age

• at 6 months of age in un-immunized mice

• in young mice immunized with sheep red blood cells

increased plasma cell number ( J:266124 )

• in young mice immunized with sheep red blood cells

increased T follicular helper cell number ( J:266124 )

• at 6 months of age in un-immunized mice

• in young mice immunized with sheep red blood cells

increased IgG level ( J:266124 )

• SRBC-specific in young mice immunized with sheep red blood cells (SRBC)

increased IgG1 level ( J:266124 )

• following immunization with 4-hydroxy-3-nitrophenyl linked to Keyhole Limpet Hemocyanin (KLH) (NP-KLH) in alum

Allelic Composition	Mef2b^tm2Rdf/Mef2b⁺ Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2b^tm2Rdf mutation (0 available); any Mef2b mutation (22 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

enlarged spleen ( J:265465 )

• observed occasionally at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

abnormal mature B cell morphology ( J:265465 )

• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)

• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)

increased germinal center B cell number ( J:265465 )

• 10 days after immunization with sheep red blood cells (SRBCs)

immune system

enlarged spleen ( J:265465 )

• observed occasionally at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

abnormal mature B cell morphology ( J:265465 )

• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)

• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)

increased germinal center B cell number ( J:265465 )

• 10 days after immunization with sheep red blood cells (SRBCs)

enlarged mesenteric lymph nodes ( J:265465 )

• at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

enlarged lymph nodes ( J:265465 )

• in 28% of mice at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

neoplasm

increased B cell derived lymphoma incidence ( J:265465 )

• at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

growth/size/body

enlarged spleen ( J:265465 )

• observed occasionally at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

Allelic Composition	Rev3l^tm1Rsky/Rev3l^tm1.1Rsky Tg(Cr2-cre)3Cgn/?
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rev3l^tm1.1Rsky mutation (0 available); any Rev3l mutation (120 available)
Rev3l^tm1Rsky mutation (1 available); any Rev3l mutation (120 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Chromosome aberrations in B cells of Rev3l^tm1Rsky/Rev3l^tm1.1Rsky Tg(Cr2-cre)3Cgn/0 mice

cellular

decreased B cell proliferation ( J:146453 )

• B cells stimulated in vitro in the presence of LPS or LPS + IL-4 have reduced cellular proliferation compared to controls

• viability of stimulated cells drops dramatically three days after stimulation

spontaneous chromosome breakage ( J:146453 )

• B cells undergoing class switch recombination have a 4-fold greater frequency of irregular chromosomes (broken chromosomes, chromosome fusions, and translocations) than controls

• many of these chromosome breaks occur at the IgH locus

• when B cells are activated without class switch recombination, there is still an increased frequency of chromosome breaks but none occur at the IgH locus

immune system

decreased B cell proliferation ( J:146453 )

• B cells stimulated in vitro in the presence of LPS or LPS + IL-4 have reduced cellular proliferation compared to controls

• viability of stimulated cells drops dramatically three days after stimulation

abnormal class switch recombination ( J:146453 )

• there is a 2-3 fold reduced frequency of B cells that switch to IgG3 or IgG1 when stimulated in vitro in the presence of LPS or LPS + IL-4, respectively, as compared to controls

• this reduced class switch recombination is still observed when comparisons are made between B cells that have undergone the same number of divisions

• S-mu switch regions have less somatic mutations than controls due to mutant cells having less opportunity to accumulate mutations before switching

abnormal somatic hypermutation frequency ( J:146453 )

• the percentage of mutations that occur in the recombined IgH locus of germinal center B cells is roughly half that of controls

• the mutation percentage drops to less than a third of controls when germinal center B cells are pre-screened to keep only those that have excised the floxed allele

• almost 50% of all sequences derived from these cells contained only one mutation, whereas close to 80% of the sequences derived from controls had multiple mutations

decreased germinal center B cell number ( J:146453 )

• there is a 2-3 fold reduction in the number of germinal center B cells

• this population is slightly enriched for cells that have escaped cre-mediated deletion of the floxed allele

decreased IgG1 level ( J:146453 )

• sera levels of antigen-specific IgG1 and Iglambda are half that of controls after immunization

hematopoietic system

decreased B cell proliferation ( J:146453 )

• B cells stimulated in vitro in the presence of LPS or LPS + IL-4 have reduced cellular proliferation compared to controls

• viability of stimulated cells drops dramatically three days after stimulation

abnormal class switch recombination ( J:146453 )

• there is a 2-3 fold reduced frequency of B cells that switch to IgG3 or IgG1 when stimulated in vitro in the presence of LPS or LPS + IL-4, respectively, as compared to controls

• this reduced class switch recombination is still observed when comparisons are made between B cells that have undergone the same number of divisions

• S-mu switch regions have less somatic mutations than controls due to mutant cells having less opportunity to accumulate mutations before switching

abnormal somatic hypermutation frequency ( J:146453 )

• the percentage of mutations that occur in the recombined IgH locus of germinal center B cells is roughly half that of controls

• the mutation percentage drops to less than a third of controls when germinal center B cells are pre-screened to keep only those that have excised the floxed allele

• almost 50% of all sequences derived from these cells contained only one mutation, whereas close to 80% of the sequences derived from controls had multiple mutations

decreased germinal center B cell number ( J:146453 )

• there is a 2-3 fold reduction in the number of germinal center B cells

• this population is slightly enriched for cells that have escaped cre-mediated deletion of the floxed allele

decreased IgG1 level ( J:146453 )

• sera levels of antigen-specific IgG1 and Iglambda are half that of controls after immunization

Allelic Composition	Gt(ROSA)26Sor^{tm7(Pik3ca,EGFP)Rsky}/Gt(ROSA)26Sor^{tm7(Pik3ca,EGFP)Rsky} Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm7(Pik3ca*,EGFP)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:157297 )

• mice die soon after birth

Allelic Composition	Ebf1^tm1.1Rug/Ebf1^tm1.1Rug Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf1^tm1.1Rug mutation (0 available); any Ebf1 mutation (74 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B-1 B cell number ( J:182210 )

• almost complete loss

decreased marginal zone B cell number ( J:182210 )

hematopoietic system

decreased B-1 B cell number ( J:182210 )

• almost complete loss

decreased marginal zone B cell number ( J:182210 )

Allelic Composition	Lig4^tm3.1Fwa/Lig4^tm3.1Fwa Tg(Cr2-cre)3Cgn/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4^tm3.1Fwa mutation (0 available); any Lig4 mutation (46 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:157537 )

• mice exhibit similar class switch recombination defects observed in Lig4^tm1Fwa Igh^tm2Cgn Igk^tm1Rsky Trp53^tm1Tyj homozygotes

hematopoietic system

abnormal class switch recombination ( J:157537 )

• mice exhibit similar class switch recombination defects observed in Lig4^tm1Fwa Igh^tm2Cgn Igk^tm1Rsky Trp53^tm1Tyj homozygotes

Allelic Composition	Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	Not Specified

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B cell number ( J:79299 )

• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes

decreased follicular B cell number ( J:79299 )

decreased marginal zone B cell number ( J:79299 )

immune system

decreased B cell number ( J:79299 )

• B cell numbers are reduced 50% in the bone marrow, by about 2/3 in follicular and marginal zones of the spleen, and strongly reduced in the inguinal lymph nodes

decreased follicular B cell number ( J:79299 )

decreased marginal zone B cell number ( J:79299 )

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