Phenotypes associated with this allele

• Allele Symbol: Pax3^{tm3(Pax7)Buck}
• Allele Name: targeted mutation 3, Margaret Buckingham
• Allele ID: MGI:3047631
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax3^tm3(Pax7)Buck/Pax3^tm3(Pax7)Buck	involves: 129S2/SvPas	MGI:3047687
ht2	Pax3^tm3(Pax7)Buck/Pax3^+	involves: 129S2/SvPas	MGI:3047700

Genotype
MGI:3047687

hm1

• Allelic Composition: Pax3^{tm3(Pax7)Buck}/Pax3^{tm3(Pax7)Buck}
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal muscle development ( J:90568 )

• limb muscles are absent

nervous system

spina bifida ( J:90568 )

• failure of neural tube closure is seen

absent dorsal root ganglion ( J:90568 )

• the dorsal root ganglia are missing

embryo

abnormal neural crest cell migration ( J:90568 )

• deficient neural crest cell migration is seen

spina bifida ( J:90568 )

• failure of neural tube closure is seen

cellular

abnormal neural crest cell migration ( J:90568 )

• deficient neural crest cell migration is seen

Genotype
MGI:3047700

ht2

• Allelic Composition: Pax3^{tm3(Pax7)Buck}/Pax3⁺
• Genetic Background: involves: 129S2/SvPas

pigmentation

variable depigmentation ( J:90568 )

• white spotting similar to that seen in Pax3^Sp heterozygotes is seen

integument

variable depigmentation ( J:90568 )

• white spotting similar to that seen in Pax3^Sp heterozygotes is seen