Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gabra6tm2(cre)Wwis targeted mutation 2, W Wisden MGI:3047798 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• shows no defect in balance and coordination
• no anatomical abnormality in cerebella
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal cerebellar histology, synaptic morphology and synaptic function
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• resting membrane potential mediated by chloride ion extrusion in granule cells is disrupted compared to in wild-type mice
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• chloride ion concentration is increased 2-fold compared to in wild-type mice
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• spontaneous Purkinje cell firing is irregular compared to in wild-type cells
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| N |
• mice exhibit normal short-term, gain-decreased motor learning and dark, gain consolidation
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• mice exhibit impaired vestibuloocular reflex in the dark phase adjustment from day 4 (long-term memory consolidation) compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit impairment in vestibuloocular reflex in the dark decrease learning and dark, gain consolidation compared with wild-type mice
• mice exhibit impaired vestibuloocular reflex in the dark phase adjustment from day 4 (long-term memory consolidation) compared with wild-type mice
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• mice exhibit impairment in vestibuloocular reflex in the dark decrease learning and dark, gain consolidation compared with wild-type mice
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• mice exhibit decreased gain in optokinetic reflex compared with wild-type mice
• mice exhibit a phase lag during optokinetic reflex compared with wild-type mice
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• mice exhibit a phase lag during vestibuloocular reflex in the dark compared with wild-type mice
• mice exhibit impairment in vestibuloocular reflex in the dark decrease learning compared with wild-type mice
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• mice exhibit a phase lag during vestibuloocular reflex in the light compared with wild-type mice
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| N |
• mice exhibit normal cerebellar histology, synaptic morphology and synaptic function
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• mice exhibit reduced GABA-induced chloride ion currents compared with wild-type mice that is not as severe as in Slc12a5tm2.1Tjj/Slc12a5tm2.1Tjj Tg(Pcp2-cre)2Mpin mice
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• mice exhibit a phase lag during vestibuloocular reflex in the dark compared with wild-type mice
• mice exhibit impairment in vestibuloocular reflex in the dark decrease learning compared with wild-type mice
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• mice exhibit a phase lag during vestibuloocular reflex in the light compared with wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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