Analysis Tools|
Allele Symbol Allele Name Allele ID |
Dnmt3atm3.2Enl targeted mutation 3.2, En Li MGI:3047824 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes die at about 4 weeks of age
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• homozygotes appear normal at birth but do not grow as well as wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• testes weight is greatly reduced at 11 weeks of age
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• at P11 the number of spermatogonia are reduced and by 11 weeks of age few spermatogonia and no spermatocytes, spermatids, or spermatozoa are seen
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• testes weight is greatly reduced at 11 weeks of age
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• all embryos die around E10.5 with open neural tubes, absent branchial arches and pale skin
• this is a maternal effect mutation resulting from impaired maternal imprinting
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• no pregnancies result from crossing mutant males with wild-type females
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• at P11 the number of spermatogonia are reduced and by 11 weeks of age few spermatogonia and no spermatocytes, spermatids, or spermatozoa are seen
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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