Analysis Tools
integument
| N |
• normal coat and whiskers
|
growth/size/body
|
• 60% of mice with craniofacial abnormalities due to abnormal nasal bones
|
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• throughout life
|
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• significantly reduced body weight largely due to reduced abdominal fat
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adipose tissue
craniofacial
|
• 60% of mice with craniofacial abnormalities due to abnormal nasal bones
|
behavior/neurological
 N |
• behavior testing was all done using male mice on a C57BL/6 background
• normal reflexes
• normal activity in an open field test
|
|
|
• impaired learning in both context and cue-based tests
|
|
|
• increased time spent interacting with a novel inanimate object leading to more normal gooming levels
|
|
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• when alone
|
|
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• poorer coordination displayed on a rotarod test and walking on a horizontal wooden dowel
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|
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• reduced grip strength displayed by poorer performance in a hanging wire test
|
|
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• increased levels of interaction with a strange mouse
|
nervous system
|
• significantly reduced neurite length relative to controls after six hours of neuron culture
|
skeleton
|
• 60% of mice with craniofacial abnormalities due to abnormal nasal bones
|
respiratory system
|
• 60% of mice with craniofacial abnormalities due to abnormal nasal bones
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autosomal dominant intellectual developmental disorder | DOID:0060307 |
OMIM:PS156200 |
J:212073 | |
