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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mtdh+
wild type
MGI:3049039
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Mtdhtm1.2Dsar/Mtdh+ either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N) MGI:5810064
cx2
MtdhGt(XB780)Byg/Mtdh+
Tg(MMTV-PyVT)634Mul/0
FVB.Cg-MtdhGt(XB780)Byg Tg(MMTV-PyVT)634Mul MGI:5649043
cx3
MtdhGt(XB780)Byg/Mtdh+
Tg(Wnt1)1Hev/0
FVB.Cg-MtdhGt(XB780)Byg Tg(Wnt1)1Hev MGI:5649042


Genotype
MGI:5810064
ht1
Allelic
Composition
Mtdhtm1.2Dsar/Mtdh+
Genetic
Background
either: B6.129(FVB)-Mtdhtm1.2Dsar or (129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mtdhtm1.2Dsar mutation (1 available); any Mtdh mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• small litter sizes (1-2 pups/litter)




Genotype
MGI:5649043
cx2
Allelic
Composition
MtdhGt(XB780)Byg/Mtdh+
Tg(MMTV-PyVT)634Mul/0
Genetic
Background
FVB.Cg-MtdhGt(XB780)Byg Tg(MMTV-PyVT)634Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MtdhGt(XB780)Byg mutation (0 available); any Mtdh mutation (32 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• total tumor burden is reduced to 54% of transgenic mice wild-type for Mtdh

integument
• total tumor burden is reduced to 54% of transgenic mice wild-type for Mtdh

endocrine/exocrine glands
• total tumor burden is reduced to 54% of transgenic mice wild-type for Mtdh




Genotype
MGI:5649042
cx3
Allelic
Composition
MtdhGt(XB780)Byg/Mtdh+
Tg(Wnt1)1Hev/0
Genetic
Background
FVB.Cg-MtdhGt(XB780)Byg Tg(Wnt1)1Hev
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MtdhGt(XB780)Byg mutation (0 available); any Mtdh mutation (32 available)
Tg(Wnt1)1Hev mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• no tumors are detected in 35% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh
• the number of tumors in mice with tumors is also reduced compared to transgenic mice wild-type for Mtdh
• no tumors are detected in 35% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh

endocrine/exocrine glands
• no tumors are detected in 35% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh
• the number of tumors in mice with tumors is also reduced compared to transgenic mice wild-type for Mtdh

integument
• no tumors are detected in 35% of mice at 300 days of age unlike in transgenic mice wild-type for Mtdh
• the number of tumors in mice with tumors is also reduced compared to transgenic mice wild-type for Mtdh





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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory