Phenotypes associated with this allele

• Allele Symbol: Hprt1^tm1Dhm
• Allele Name: targeted mutation 1, David H MacLennan
• Allele ID: MGI:3050087
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hprt1^tm1Dhm/Hprt1^tm1Dhm	involves: 129P2/OlaHsd	MGI:3050227
cx2	Hprt1^tm1Dhm/Hprt1^tm1Dhm Pln^tm1Egk/Pln^tm1Egk	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:3653918
cx3	Hprt1^tm1Dhm/Y Pln^tm1Egk/Pln^tm1Egk	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:3653919
ot4	Hprt1^tm1Dhm/Y	involves: 129P2/OlaHsd	MGI:3050226

Genotype
MGI:3050227

hm1

• Allelic Composition: Hprt1^tm1Dhm/Hprt1^tm1Dhm
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased heart weight ( J:91410 )

♀ • the ratio of left ventricular weight to both tibia length and body weight is increased at 10 weeks of age

cardiac hypertrophy ( J:106044 )

♀ • exhibit mild hypertrophy

decreased cardiac muscle contractility ( J:106044 )

♀ • isolated cardiac myocytes exhibit a significant decrease in fractional cell shortening and smaller dL/dT values

decreased heart ventricle muscle contractility ( J:91410 )

♀ • the first derivatives of minimum and maximum left ventricular pressure, the fractional shortening, velocity of circumferential shortening corrected, and peak early-filling transmitral diastolic wave velocity are all decreased

♀ • treatment with isoproternol, a beta-adrenergic activator, reversed cardiac impairment in mutant hearts

abnormal cardiac muscle relaxation ( J:106044 )

♀ • isolated cardiac myocytes exhibit lower relaxation rates (-dL/dt) than wild-type

abnormal myocardial fiber physiology ( J:106044 )

♀ • under baseline conditions, left ventricular myocytes exhibit lower calcium transient amplitude and slower calcium transient decays

muscle

decreased cardiac muscle contractility ( J:106044 )

♀ • isolated cardiac myocytes exhibit a significant decrease in fractional cell shortening and smaller dL/dT values

decreased heart ventricle muscle contractility ( J:91410 )

♀ • the first derivatives of minimum and maximum left ventricular pressure, the fractional shortening, velocity of circumferential shortening corrected, and peak early-filling transmitral diastolic wave velocity are all decreased

♀ • treatment with isoproternol, a beta-adrenergic activator, reversed cardiac impairment in mutant hearts

abnormal cardiac muscle relaxation ( J:106044 )

♀ • isolated cardiac myocytes exhibit lower relaxation rates (-dL/dt) than wild-type

growth/size/body

increased heart weight ( J:91410 )

♀ • the ratio of left ventricular weight to both tibia length and body weight is increased at 10 weeks of age

cardiac hypertrophy ( J:106044 )

♀ • exhibit mild hypertrophy

Genotype
MGI:3653918

cx2

• Allelic Composition: Hprt1^tm1Dhm/Hprt1^tm1Dhm; Pln^tm1Egk/Pln^tm1Egk
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

cardiovascular system

increased cardiac muscle contractility ( J:106044 )

♀ • isolated cardiac myocytes exhibit enhanced fractional cell shortening and higher dL/dT values compared to wild-type, however this shortening and dL/dT values are less than that seen in the single homozygous Pln mutant mouse

abnormal cardiac muscle relaxation ( J:106044 )

♀ • isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type but lower than that seen in single homozygous Pln mutant mice

abnormal myocardial fiber physiology ( J:106044 )

♀ • under baseline conditions, left ventricular myocytes exhibit faster calcium transient decays than wild-type, however they are slower than in single homozygous Pln mutant mice

muscle

increased cardiac muscle contractility ( J:106044 )

♀ • isolated cardiac myocytes exhibit enhanced fractional cell shortening and higher dL/dT values compared to wild-type, however this shortening and dL/dT values are less than that seen in the single homozygous Pln mutant mouse

abnormal cardiac muscle relaxation ( J:106044 )

♀ • isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type but lower than that seen in single homozygous Pln mutant mice

Genotype
MGI:3653919

cx3

• Allelic Composition: Hprt1^tm1Dhm/Y; Pln^tm1Egk/Pln^tm1Egk
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

cardiovascular system

increased cardiac muscle contractility ( J:106044 )

♂ • isolated cardiac myocytes exhibit enhanced fractional cell shortening and higher dL/dT values compared to wild-type, however this shortening and dL/dT values are less than that seen in the single homozygous Pln mutant mouse

abnormal cardiac muscle relaxation ( J:106044 )

♂ • isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type but lower than that seen in single homozygous Pln mutant mice

abnormal myocardial fiber physiology ( J:106044 )

♂ • under baseline conditions, left ventricular myocytes exhibit faster calcium transient decays than wild-type, however they are slower than in single homozygous Pln mutant mice

muscle

increased cardiac muscle contractility ( J:106044 )

♂ • isolated cardiac myocytes exhibit enhanced fractional cell shortening and higher dL/dT values compared to wild-type, however this shortening and dL/dT values are less than that seen in the single homozygous Pln mutant mouse

abnormal cardiac muscle relaxation ( J:106044 )

♂ • isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type but lower than that seen in single homozygous Pln mutant mice

Genotype
MGI:3050226

ot4

• Allelic Composition: Hprt1^tm1Dhm/Y
• Genetic Background: involves: 129P2/OlaHsd

cardiovascular system

increased heart weight ( J:91410 )

♂ • the ratio of left ventricular weight to both tibia length and body weight is increased at 10 weeks of age

cardiac hypertrophy ( J:106044 )

♂ • exhibit mild hypertrophy

decreased cardiac muscle contractility ( J:106044 )

♂ • isolated cardiac myocytes exhibit a significant decrease in fractional cell shortening and smaller dL/dT values

decreased heart ventricle muscle contractility ( J:91410 )

♂ • the first derivatives of minimum and maximum left ventricular pressure, the fractional shortening, velocity of circumferential shortening corrected, and peak early-filling transmitral diastolic wave velocity are all decreased

♂ • treatment with isoproternol, a beta-adrenergic activator, reversed cardiac impairment in mutant hearts

abnormal cardiac muscle relaxation ( J:106044 )

♂ • isolated cardiac myocytes exhibit lower relaxation rates (-dL/dt) than wild-type

abnormal myocardial fiber physiology ( J:106044 )

♂ • under baseline conditions, left ventricular myocytes exhibit lower calcium transient amplitude and slower calcium transient decays

muscle

decreased cardiac muscle contractility ( J:106044 )

♂ • isolated cardiac myocytes exhibit a significant decrease in fractional cell shortening and smaller dL/dT values

decreased heart ventricle muscle contractility ( J:91410 )

♂ • the first derivatives of minimum and maximum left ventricular pressure, the fractional shortening, velocity of circumferential shortening corrected, and peak early-filling transmitral diastolic wave velocity are all decreased

♂ • treatment with isoproternol, a beta-adrenergic activator, reversed cardiac impairment in mutant hearts

abnormal cardiac muscle relaxation ( J:106044 )

♂ • isolated cardiac myocytes exhibit lower relaxation rates (-dL/dt) than wild-type

growth/size/body

increased heart weight ( J:91410 )

♂ • the ratio of left ventricular weight to both tibia length and body weight is increased at 10 weeks of age

cardiac hypertrophy ( J:106044 )

♂ • exhibit mild hypertrophy