All Phenotypes Fzd6<tm1Nat> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fzd6^tm1Nat
targeted mutation 1, Jeremy Nathans
MGI:3050103

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fzd6^tm1Nat/Fzd6^tm1Nat	involves: 129	MGI:3050218
hm2	Fzd6^tm1Nat/Fzd6^tm1Nat	involves: 129 * C57BL/6	MGI:3050219
cx3	Astn2^tm1.2Nat/Astn2^tm1.2Nat Fzd6^tm1Nat/Fzd6^tm1Nat	involves: 129 * 129S6/SvEvTac * BALB/cJ * C57BL/6 * CBA	MGI:6107705
cx4	Astn2^ridge/Astn2^ridge Fzd6^tm1Nat/Fzd6^tm1Nat	involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA	MGI:6107706
cx5	Fzd3^tm1Nat/Fzd3^tm1Nat Fzd6^tm1Nat/Fzd6^tm1Nat	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3652561
cx6	Fzd3^tm1Nat/Fzd3⁺ Fzd6^tm1Nat/Fzd6^tm1Nat	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3652560

Allelic Composition	Fzd6^tm1Nat/Fzd6^tm1Nat
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd6^tm1Nat mutation (1 available); any Fzd6 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal hair follicle orientation ( J:91412 )

• abnormal hair patterns are seen on the dorsal surface of the head, the hind feet, the back, and chest

• in the regions with abnormal hair patterns hair follicles do not conform to the parallel arrangement seen elsewhere

• penetrance is higher on a pure 129 background than on a mixed 129 - C57BL/6 background

Allelic Composition	Fzd6^tm1Nat/Fzd6^tm1Nat
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd6^tm1Nat mutation (1 available); any Fzd6 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal hair follicle orientation ( J:91412 )

• abnormal hair patterns are seen on the dorsal surface of the head, the hind feet, the back, and chest

• in the regions with abnormal hair patterns hair follicles do not conform to the parallel arrangement seen elsewhere

• penetrance is higher on a pure 129 background than on a mixed 129 - C57BL/6 background

Allelic Composition	Astn2^tm1.2Nat/Astn2^tm1.2Nat Fzd6^tm1Nat/Fzd6^tm1Nat
Genetic Background	involves: 129 * 129S6/SvEvTac * BALB/cJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Astn2^tm1.2Nat mutation (0 available); any Astn2 mutation (61 available)
Fzd6^tm1Nat mutation (1 available); any Fzd6 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal hair texture ( J:228899 )

• hair ridge on back coat between upper and lower back

abnormal hair follicle orientation ( J:228899 )

• posterior-to-anterior and weaker lateral directional bias on lower back

Allelic Composition	Astn2^ridge/Astn2^ridge Fzd6^tm1Nat/Fzd6^tm1Nat
Genetic Background	involves: 129 * 129X1/SvJ * BALB/cJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Astn2^ridge mutation (1 available); any Astn2 mutation (61 available)
Fzd6^tm1Nat mutation (1 available); any Fzd6 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal hair texture ( J:228899 )

• hair ridge on back coat between upper and lower back

abnormal hair follicle orientation ( J:228899 )

• posterior-to-anterior and weaker lateral directional bias on lower back

Allelic Composition	Fzd3^tm1Nat/Fzd3^tm1Nat Fzd6^tm1Nat/Fzd6^tm1Nat
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd3^tm1Nat mutation (1 available); any Fzd3 mutation (32 available)
Fzd6^tm1Nat mutation (1 available); any Fzd6 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:105752 )

• all die within minutes of birth

nervous system

open neural tube ( J:105752 )

• 100% penetrance

abnormal orientation of inner hair cell stereociliary bundles ( J:105752 )

• most severe hair bundle orientation defects in the inner hair cells

abnormal cochlear outer hair cell morphology ( J:105752 )

• less abnormality in the outer row of outer hair cells

• minimal abnormality in the inner two rows of outer hair cells

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:105752 )

N	• utricle and saccule hair cells of the vestibule are more or less normal

abnormal cochlea morphology ( J:105752 )

abnormal orientation of inner hair cell stereociliary bundles ( J:105752 )

• most severe hair bundle orientation defects in the inner hair cells

abnormal cochlear outer hair cell morphology ( J:105752 )

• less abnormality in the outer row of outer hair cells

• minimal abnormality in the inner two rows of outer hair cells

abnormal tectorial membrane morphology ( J:105752 )

• underdeveloped

abnormal crista ampullaris morphology ( J:105752 )

• hair bundle orientation defects in the cristae

limbs/digits/tail

curly tail ( J:105752 )

vision/eye

eyelids open at birth ( J:105752 )

• in about 10% of mice, eyelids fail to fuse

embryo

open neural tube ( J:105752 )

• 100% penetrance

Allelic Composition	Fzd3^tm1Nat/Fzd3⁺ Fzd6^tm1Nat/Fzd6^tm1Nat
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

oligozoospermia ( J:105752 )

• 10 fold reduction in sperm count

reduced male fertility ( J:105752 )

cellular

oligozoospermia ( J:105752 )

• 10 fold reduction in sperm count

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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