Phenotypes associated with this allele

• Allele Symbol: Btn1a1^tm2Ihm
• Allele Name: targeted mutation 2, Ian H Mather
• Allele ID: MGI:3050156
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Btn1a1^tm2Ihm/Btn1a1^tm2Ihm	involves: 129S6/SvEvTac * C57BL/6	MGI:3051614

Genotype
MGI:3051614

hm1

• Allelic Composition: Btn1a1^tm2Ihm/Btn1a1^tm2Ihm
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland morphology ( J:91440 )

♀ • secretory cells contain large lipid droplets which may break through holes in the apical surface filling the luminal spaces

abnormal lactation ( J:91440 )

♀ • lactation is compromised with only 50 - 60% of pups surviving to weaning

abnormal milk composition ( J:91440 )

♀ • milk contains 25-35% (wt/vol) lipid a 50% increase compared to wild-type mice

♀ • many large lipid droplets are seen in the milk from homozygous mutants

integument

abnormal mammary gland morphology ( J:91440 )

♀ • secretory cells contain large lipid droplets which may break through holes in the apical surface filling the luminal spaces

abnormal lactation ( J:91440 )

♀ • lactation is compromised with only 50 - 60% of pups surviving to weaning

abnormal milk composition ( J:91440 )

♀ • milk contains 25-35% (wt/vol) lipid a 50% increase compared to wild-type mice

♀ • many large lipid droplets are seen in the milk from homozygous mutants