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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ntrk2tm1Jom
targeted mutation 1, James O McNamara
MGI:3050229
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ntrk2tm1Jom/Ntrk2tm1Jom
Tg(Syn1-cre)671Jxm/0 		involves: 129/Sv * C57BL/6 * ICR MGI:3051974
cn2
 		Ntrk2tm1Jom/Ntrk2+
Tg(Syn1-cre)671Jxm/0 		involves: 129/Sv * C57BL/6 * ICR MGI:3051975
cn3
 		Ntrk2tm1Jom/Ntrk2tm1Jom
Tg(GFAP-cre)25Mes/0 		involves: FVB/N MGI:3612962


Genotype
MGI:3051974
cn1
Allelic
Composition		 Ntrk2tm1Jom/Ntrk2tm1Jom
Tg(Syn1-cre)671Jxm/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm1Jom mutation (0 available); any Ntrk2 mutation (66 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased kindling response ( J:91467 )
• kindling could not be induced even after 48 to 50 stimulations and an increase in the current required to induce the initial electrographic seizure is seen
• electroconvulsive shock can induce tonic-clonic seizures (the behavioral endpoint of kindling) in mutants

nervous system
decreased kindling response ( J:91467 )
• kindling could not be induced even after 48 to 50 stimulations and an increase in the current required to induce the initial electrographic seizure is seen
• electroconvulsive shock can induce tonic-clonic seizures (the behavioral endpoint of kindling) in mutants




Genotype
MGI:3051975
cn2
Allelic
Composition		 Ntrk2tm1Jom/Ntrk2+
Tg(Syn1-cre)671Jxm/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm1Jom mutation (0 available); any Ntrk2 mutation (66 available)
Tg(Syn1-cre)671Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
decreased kindling response ( J:91467 )
• a modest inhibition of kindling development is seen with an increased number of stimulations required to induce the third consecutive class 4 or class 5 seizure

nervous system
decreased kindling response ( J:91467 )
• a modest inhibition of kindling development is seen with an increased number of stimulations required to induce the third consecutive class 4 or class 5 seizure




Genotype
MGI:3612962
cn3
Allelic
Composition		 Ntrk2tm1Jom/Ntrk2tm1Jom
Tg(GFAP-cre)25Mes/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntrk2tm1Jom mutation (0 available); any Ntrk2 mutation (66 available)
Tg(GFAP-cre)25Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:103935 )
N
• no defects in barrel cortex formation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory