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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(PDGFB-Hyou1)#Tam
transgene insertion #, Michio Tamatani
MGI:3050236
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
 		Tg(PDGFB-Hyou1)#Tam/0 involves: BALB/c * C57BL/6 MGI:3050243
tg2
 		Tg(PDGFB-Hyou1)#Tam/0 Not Specified MGI:3050242


Genotype
MGI:3050243
tg1
Allelic
Composition		 Tg(PDGFB-Hyou1)#Tam/0
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased susceptibility to neuronal excitotoxicity ( J:91396 )
• kainate causes reduced excitotoxicity induced neuronal cell death resulting from excitotoxicity in transgenics compared to wild-type mice
abnormal response to CNS ischemic injury ( J:67962 )
• 24 hours after permanent middle cerebral artery occlusion neurological deficit and infarct volume are significantly reduced

nervous system
decreased susceptibility to neuronal excitotoxicity ( J:91396 )
• kainate causes reduced excitotoxicity induced neuronal cell death resulting from excitotoxicity in transgenics compared to wild-type mice
abnormal response to CNS ischemic injury ( J:67962 )
• 24 hours after permanent middle cerebral artery occlusion neurological deficit and infarct volume are significantly reduced

cellular
decreased susceptibility to neuronal excitotoxicity ( J:91396 )
• kainate causes reduced excitotoxicity induced neuronal cell death resulting from excitotoxicity in transgenics compared to wild-type mice




Genotype
MGI:3050242
tg2
Allelic
Composition		 Tg(PDGFB-Hyou1)#Tam/0
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal response to CNS ischemic injury ( J:91007 )
• 1 hour but not 3 hours after occlusion of the middle cerebral artery, cortical infarct volume was significantly smaller in transgenics compared to mice heterozygous for Hyou1tm1Oga

homeostasis/metabolism
abnormal response to CNS ischemic injury ( J:91007 )
• 1 hour but not 3 hours after occlusion of the middle cerebral artery, cortical infarct volume was significantly smaller in transgenics compared to mice heterozygous for Hyou1tm1Oga




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory