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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Csktm1Tara
targeted mutation 1, Alexander Tarakovsky
MGI:3050293
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Csktm1Tara/Csktm1Tara
Tg(Mx1-cre)1Cgn/0 		involves: 129P2/OlaHsd * C57BL/6 * CB20 * CBA MGI:3050322
cn2
 		Csktm1Tara/Csktm2Tara
Elanetm1(cre)Roes/Elane+ 		involves: 129P2/OlaHsd * CB20 * C57BL/6 MGI:3050324


Genotype
MGI:3050322
cn1
Allelic
Composition		 Csktm1Tara/Csktm1Tara
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CB20 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csktm1Tara mutation (1 available); any Csk mutation (27 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
enlarged thymus ( J:49654 )
• thymus is large and contains both double positive and CD4+ cells
abnormal CD4-positive T cell differentiation ( J:49654 )
• a population of peripheral lymphocytes are produced which are CD4+ but with a 2-3 fold reduction in surface expression of CD4
absent CD8-positive, alpha-beta T cells ( J:49654 )
• CD8 single positive cells are absent

immune system
enlarged thymus ( J:49654 )
• thymus is large and contains both double positive and CD4+ cells
abnormal CD4-positive T cell differentiation ( J:49654 )
• a population of peripheral lymphocytes are produced which are CD4+ but with a 2-3 fold reduction in surface expression of CD4
absent CD8-positive, alpha-beta T cells ( J:49654 )
• CD8 single positive cells are absent

endocrine/exocrine glands
enlarged thymus ( J:49654 )
• thymus is large and contains both double positive and CD4+ cells




Genotype
MGI:3050324
cn2
Allelic
Composition		 Csktm1Tara/Csktm2Tara
Elanetm1(cre)Roes/Elane+
Genetic
Background		 involves: 129P2/OlaHsd * CB20 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csktm1Tara mutation (1 available); any Csk mutation (27 available)
Csktm2Tara mutation (0 available); any Csk mutation (27 available)
Elanetm1(cre)Roes mutation (5 available); any Elane mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal myelopoiesis ( J:89716 )
• increased myelopoietic activity in bone marrow
abnormal granulocyte physiology ( J:89716 )
• increased cell adhesion

immune system
abnormal myelopoiesis ( J:89716 )
• increased myelopoietic activity in bone marrow
abnormal granulocyte physiology ( J:89716 )
• increased cell adhesion
increased acute inflammation ( J:89716 )
• inflammatory disorder in almost all mice after 6 weeks of age of CD4
• dermatitis-like symptomes
• inflammation of eyelids and ears
• acute pulmonary inflammation and perivascular accumulation of polymorphonuclear granulocytes
• granulocytic infiltration of dorsal deep dermis and subcutis of extremities
increased susceptibility to bacterial infection ( J:89716 )
• increased sensitivity to lipopolysaccharide




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory