Phenotypes associated with this allele

• Allele Symbol: Tbk1^tm1Yeh
• Allele Name: targeted mutation 1, Wen-Chen Yeh
• Allele ID: MGI:3050522
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbk1^tm1Yeh/Tbk1^tm1Yeh	involves: 129P2/OlaHsd * C57BL/6J	MGI:3050528
cx2	Tbk1^tm1Yeh/Tbk1^tm1Yeh Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak	involves: 129P2/OlaHsd * C57BL/6J	MGI:3050533

Genotype
MGI:3050528

hm1

• Allelic Composition: Tbk1^tm1Yeh/Tbk1^tm1Yeh
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:91653 )

• all mutant embryos die between E14.5-15.5

cardiovascular system

liver hemorrhage ( J:91653 )

• at E14.5 liver hemorrhage is seen

liver/biliary system

liver hemorrhage ( J:91653 )

• at E14.5 liver hemorrhage is seen

liver degeneration ( J:91653 )

• at E13.5 mild focal liver degeneration and apoptosis is seen, by E14.5 extensive apoptosis is seen throughout the liver

integument

pallor ( J:91653 )

• at E14.5 mutant embryos appear pale

Genotype
MGI:3050533

cx2

• Allelic Composition: Tbk1^tm1Yeh/Tbk1^tm1Yeh; Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

mortality/aging ( J:91653 )

N • double homozygotes develop to term unlike Tbk1^tm1Yeh homozygotes that die at around E14.5