hematopoietic system
• a significant increase in proliferation of activated T cells is seen
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• a slight but significant increase in the number of immature myeloid lineage cells and corresponding decrease in lymphocyte numbers is seen
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cellular
• keratinocyte migration is significantly impaired
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• a significant increase in proliferation of activated T cells is seen
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immune system
• a significant increase in proliferation of activated T cells is seen
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homeostasis/metabolism
• a small but significant increase in mean tail bleeding time and a 3 fold increase in the volume of blood lost is seen
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renal/urinary system
N |
• Background Sensitivity: homozygotes on a C57BL/6 background remain healthy and exhibit histologically normal kidneys with no signs of proteinuria up to 12 months of age, whereas homozygotes on a FVB/N background develop severe glomerular disease
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integument
• keratinocyte migration is significantly impaired
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