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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cd151tm1Lka
targeted mutation 1, Leonie K Ashman
MGI:3050539
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cd151tm1Lka/Cd151tm1Lka C57BL/6-Cd151tm1Lka MGI:3050659
hm2
Cd151tm1Lka/Cd151tm1Lka FVB.B6-CD151tm1Lka MGI:5429577


Genotype
MGI:3050659
hm1
Allelic
Composition
Cd151tm1Lka/Cd151tm1Lka
Genetic
Background
C57BL/6-Cd151tm1Lka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd151tm1Lka mutation (3 available); any Cd151 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• a significant increase in proliferation of activated T cells is seen
• a slight but significant increase in the number of immature myeloid lineage cells and corresponding decrease in lymphocyte numbers is seen

cellular
• keratinocyte migration is significantly impaired
• a significant increase in proliferation of activated T cells is seen

immune system
• a significant increase in proliferation of activated T cells is seen

homeostasis/metabolism
• a small but significant increase in mean tail bleeding time and a 3 fold increase in the volume of blood lost is seen

renal/urinary system
N
• Background Sensitivity: homozygotes on a C57BL/6 background remain healthy and exhibit histologically normal kidneys with no signs of proteinuria up to 12 months of age, whereas homozygotes on a FVB/N background develop severe glomerular disease

integument
• keratinocyte migration is significantly impaired




Genotype
MGI:5429577
hm2
Allelic
Composition
Cd151tm1Lka/Cd151tm1Lka
Genetic
Background
FVB.B6-CD151tm1Lka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd151tm1Lka mutation (3 available); any Cd151 mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes die of kidney failure at around 5 months of age

renal/urinary system
• at 4-5 months of age, homozygotes display enlarged kidneys
• on a FVB/N background, proteinuria is detected as early as 5 days of age and increases progressively to become massive at 12 weeks
• Background Sensitivity: homozygotes on a C57BL/6 background remain healthy and exhibit no signs of proteinuria up to 12 months of age
• at 3 weeks of age, all glomeruli examined by SEM display some extent of podocyte damage; cell bodies appear flattened and the processes are disorganized but still present
• at 3 weeks of age, TEM analysis indicated only focal effacement of foot processes, even along the massively thickened GBM segments
• SEM analysis revealed pronounced foot process effacement by 12 weeks of age
• at 3 weeks and 12 weeks of age, homozygotes display a significant decrease in podocyte number per glomerulus (22.2% and 28.4%, respectively) relative to wild-type controls
• massive thickening and splitting of the GBM is seen as early as 5 days in some segments of glomeruli
• at 3 weeks of age, GBM disorganization is more severe and involves more capillary loops
• immunofluorescence labeling with antibodies towards laminin chains, nidogen, and collagen IV chains revealed a defect in GBM assembly and maturation
• at 3-4-weeks of age, homozygotes display extensive thickening of the GBM with no evidence of sclerotic lesions
• by 12 weeks of age, most (4 of 5) homozygotes display abnormal thickening of the GBM
• at 4 weeks of age, homozygotes exhibit mild glomerular damage consisting exclusively of GBM thickening
• by 12 week of age, all homozygotes show significantly increased kidney damage, ranging from moderate glomerular damage to more severe glomerular damage associated with tubular lesions
• at 4 weeks of age, focal thickening of the extracellular matrix is observed in some glomeruli
• by 12 weeks of age, a few homozygotes display massive glomerulosclerosis and collapse of the glomerular tuft
• at 12 weeks of age, some sclerotic glomeruli exhibit partial or complete adhesion to the Bowman's capsule
• at 12 weeks of age, 1 of 5 homozygotes displayed severe and advanced glomerular lesions associated with massive tubular dilations
• by 12 weeks of age, most (4 of 5) homozygotes display obstruction of the renal tubules with proteinaceous casts
• at 4-5 months of age, homozygotes display granular kidneys
• at 4-5 months of age, homozygotes on a FVB/N background display progressive kidney failure, eventually leading to death
• Background Sensitivity: homozygotes on a C57BL/6 background remain healthy and exhibit histologically normal kidneys up to 12 months of age

homeostasis/metabolism
• at 4-5 months of age, homozygotes appear unwell and edematous
• on a FVB/N background, proteinuria is detected as early as 5 days of age and increases progressively to become massive at 12 weeks
• Background Sensitivity: homozygotes on a C57BL/6 background remain healthy and exhibit no signs of proteinuria up to 12 months of age

growth/size/body
• at 4-5 months of age, homozygotes display enlarged kidneys





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory