Analysis Tools
mortality/aging
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• almost all mutant embryos die between E8 and E13
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cardiovascular system
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• at E9.5 shorter cardiac outflow tracts are seen compared to wild-type in embryos where chorioallantoic fusion occurs
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• epicardial layers were reduced or absent at E9.5 in embryos where chorioallantoic fusion occurs
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cellular
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• at E9.5 severe diffuse apoptosis is seen throughout the neural tube in embryos where chorioallantoic fusion occurs
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• decreased cell proliferation is seen in the labyrinth and spongiotrophoblast layers of the placenta
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embryo
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• at E9.5 severe runting is seen when chorioallantoic fusion fails, in the few cases where fusion occurs less severe runting is seen
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• at E9.5 the neural tube remains open in the forebrain region in embryos where chorioallantoic fusion occurs
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• at E10.5 atrophy of the spongiotrophoblast is seen in the few cases where chorioallantoic fusion occurs
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• at E10.5 atrophy of the labyrinth layers is seen in the few cases where chorioallantoic fusion occurs
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• failure of chorioallantoic fusion is seen in most mutants at E9.5 and E10.5
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growth/size/body
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• at E9.5 severe runting is seen when chorioallantoic fusion fails, in the few cases where fusion occurs less severe runting is seen
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nervous system
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• at E9.5 the neural tube remains open in the forebrain region in embryos where chorioallantoic fusion occurs
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