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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cnot7tm1Jpr
targeted mutation 1, Jean-Pierre Rouault
MGI:3050544
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cnot7tm1Jpr/Cnot7tm1Jpr involves: 129/Sv * C57BL/6 MGI:3051590


Genotype
MGI:3051590
hm1
Allelic
Composition		 Cnot7tm1Jpr/Cnot7tm1Jpr
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnot7tm1Jpr mutation (0 available); any Cnot7 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal testis morphology ( J:91598 )
• increased intercellular spaces are seen in mutant testis at 3 months of age
decreased Sertoli cell number ( J:91598 )
• the progressive loss of Sertoli cells can be seen in some seminiferous tubules
• large vacuoles surrounded by endoplasmic reticulum membrane are seen in Sertoli cells at 3 months of age
small seminiferous tubules ( J:91598 )
• in 12 month old males seminiferous tubules are small and severely damaged with a disorganized appearance
seminiferous tubule degeneration ( J:91598 )
• round vacuoles and necrotic cells are seen in the seminiferous tubules
• thickening of the tubular membrane is seen at 18 months of age
increased Leydig cell number ( J:91598 )
• the number of Leydig cells appears to be increased in some seminiferous tubules
• several Leydig cells show signs of necrosis at 3 months of age
decreased testis weight ( J:91598 )
• testis weights are reduced in 8 month old mutant mice but not in immature mutant mice

reproductive system
abnormal testis morphology ( J:91598 )
• increased intercellular spaces are seen in mutant testis at 3 months of age
decreased Sertoli cell number ( J:91598 )
• the progressive loss of Sertoli cells can be seen in some seminiferous tubules
• large vacuoles surrounded by endoplasmic reticulum membrane are seen in Sertoli cells at 3 months of age
small seminiferous tubules ( J:91598 )
• in 12 month old males seminiferous tubules are small and severely damaged with a disorganized appearance
seminiferous tubule degeneration ( J:91598 )
• round vacuoles and necrotic cells are seen in the seminiferous tubules
• thickening of the tubular membrane is seen at 18 months of age
increased Leydig cell number ( J:91598 )
• the number of Leydig cells appears to be increased in some seminiferous tubules
• several Leydig cells show signs of necrosis at 3 months of age
decreased testis weight ( J:91598 )
• testis weights are reduced in 8 month old mutant mice but not in immature mutant mice
abnormal male germ cell morphology ( J:91598 )
• malformed or multi nucleated cells are seen in the epididymis and seminiferous tubules
decreased male germ cell number ( J:91598 )
• shedding or absence of apical germ cells is seen in the seminiferous tubules
oligozoospermia ( J:91598 )
• mature sperm are rare or absent
male infertility ( J:91598 )
• males but not females are infertile

cellular
abnormal male germ cell morphology ( J:91598 )
• malformed or multi nucleated cells are seen in the epididymis and seminiferous tubules
decreased male germ cell number ( J:91598 )
• shedding or absence of apical germ cells is seen in the seminiferous tubules
oligozoospermia ( J:91598 )
• mature sperm are rare or absent




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11/19/2024
MGI 6.24 		The Jackson Laboratory