endocrine/exocrine glands
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• increased intercellular spaces are seen in mutant testis at 3 months of age
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• the progressive loss of Sertoli cells can be seen in some seminiferous tubules
• large vacuoles surrounded by endoplasmic reticulum membrane are seen in Sertoli cells at 3 months of age
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• in 12 month old males seminiferous tubules are small and severely damaged with a disorganized appearance
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• round vacuoles and necrotic cells are seen in the seminiferous tubules
• thickening of the tubular membrane is seen at 18 months of age
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• the number of Leydig cells appears to be increased in some seminiferous tubules
• several Leydig cells show signs of necrosis at 3 months of age
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• testis weights are reduced in 8 month old mutant mice but not in immature mutant mice
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reproductive system
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• increased intercellular spaces are seen in mutant testis at 3 months of age
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• the progressive loss of Sertoli cells can be seen in some seminiferous tubules
• large vacuoles surrounded by endoplasmic reticulum membrane are seen in Sertoli cells at 3 months of age
|
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• in 12 month old males seminiferous tubules are small and severely damaged with a disorganized appearance
|
|
• round vacuoles and necrotic cells are seen in the seminiferous tubules
• thickening of the tubular membrane is seen at 18 months of age
|
|
• the number of Leydig cells appears to be increased in some seminiferous tubules
• several Leydig cells show signs of necrosis at 3 months of age
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• testis weights are reduced in 8 month old mutant mice but not in immature mutant mice
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• malformed or multi nucleated cells are seen in the epididymis and seminiferous tubules
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• shedding or absence of apical germ cells is seen in the seminiferous tubules
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• mature sperm are rare or absent
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• males but not females are infertile
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cellular
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• malformed or multi nucleated cells are seen in the epididymis and seminiferous tubules
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• shedding or absence of apical germ cells is seen in the seminiferous tubules
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• mature sperm are rare or absent
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