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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccnb1ip1mei4
prophase defect, John Schimenti
MGI:3050548
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccnb1ip1mei4/Ccnb1ip1mei4 involves: C3HeB/FeJ * C57BL/6J MGI:3760146


Genotype
MGI:3760146
hm1
Allelic
Composition		 Ccnb1ip1mei4/Ccnb1ip1mei4
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnb1ip1mei4 mutation (0 available); any Ccnb1ip1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Meiosis is abnormal in Ccnb1ip1mei4/Ccnb1ip1mei4 male and female mice

endocrine/exocrine glands
abnormal ovary morphology ( J:86161 )
• ovarian dysmorphology
abnormal seminiferous tubule morphology ( J:86161 , J:125220 )
• seminiferous tubules lack post meiotic cell differentiation (J:86161)
• incidence of apoptosis is higher in tubules (J:125220)
small testis ( J:86161 , J:125220 )
(J:86161)
(J:125220)

reproductive system
abnormal ovary morphology ( J:86161 )
• ovarian dysmorphology
abnormal seminiferous tubule morphology ( J:86161 , J:125220 )
• seminiferous tubules lack post meiotic cell differentiation (J:86161)
• incidence of apoptosis is higher in tubules (J:125220)
small testis ( J:86161 , J:125220 )
(J:86161)
(J:125220)
abnormal oocyte morphology ( J:125220 )
• most chromosomes in oocytes fail to congress to, and align at, the metaphase plate
decreased oocyte number ( J:86161 )
• reduced numbers of oocytes
azoospermia ( J:125220 )
• males do not produce sperm and testes contain no round, elongating, or further differentiated spermatids
abnormal spermatocyte morphology ( J:125220 )
• spermatocytes undergo an early metaphase I arrest marked by aberrant chromosome congression
• metaphase spermatocytes contain abnormal metaphase and anaphase-like cells
• defective interhomolog associations in spermatocytes
• premature homolog separation in diplotene spermatocytes
abnormal meiosis ( J:86161 , J:125220 )
• meiosis arrested at first cell division (J:86161)
absent chiasmata formation ( J:125220 )
• spermatocytes fail to form chiasmata
abnormal female meiosis ( J:125220 )
• metaphase I chromosome structures occur abnormally in oocytes
arrest of male meiosis ( J:125220 )
• spermatocytes undergo an early metaphase I arrest marked by aberrant chromosome congression
infertility ( J:86161 )
• sterility in both sexes

cellular
abnormal oocyte morphology ( J:125220 )
• most chromosomes in oocytes fail to congress to, and align at, the metaphase plate
decreased oocyte number ( J:86161 )
• reduced numbers of oocytes
azoospermia ( J:125220 )
• males do not produce sperm and testes contain no round, elongating, or further differentiated spermatids
abnormal spermatocyte morphology ( J:125220 )
• spermatocytes undergo an early metaphase I arrest marked by aberrant chromosome congression
• metaphase spermatocytes contain abnormal metaphase and anaphase-like cells
• defective interhomolog associations in spermatocytes
• premature homolog separation in diplotene spermatocytes
abnormal meiosis ( J:86161 , J:125220 )
• meiosis arrested at first cell division (J:86161)
absent chiasmata formation ( J:125220 )
• spermatocytes fail to form chiasmata
abnormal female meiosis ( J:125220 )
• metaphase I chromosome structures occur abnormally in oocytes
arrest of male meiosis ( J:125220 )
• spermatocytes undergo an early metaphase I arrest marked by aberrant chromosome congression




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory