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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Akap9mei2-5
male sterility, John Schimenti
MGI:3050560
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Akap9mei2-5/Akap9mei2-5 involves: 129S1/Sv MGI:5516019
hm2
 		Akap9mei2-5/Akap9mei2-5 involves: 129S1/Sv * C57BL/6 MGI:3050574
ht3
 		Akap9mei2-5/Akap9repro12 involves: 129S1/Sv * C57BL/6J MGI:5516021


Genotype
MGI:5516019
hm1
Allelic
Composition		 Akap9mei2-5/Akap9mei2-5
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap9mei2-5 mutation (0 available); any Akap9 mutation (181 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal Sertoli cell development ( J:198499 )
• high number of immature Sertoli cells
abnormal spermatogenesis ( J:198499 )
• severely impaired
• however, progression through meiosis I is normal
azoospermia ( J:198499 )
• devoid of mature spermatozoa
abnormal spermatocyte morphology ( J:198499 )
• irregular primary spermatocyte localization

endocrine/exocrine glands
abnormal Sertoli cell development ( J:198499 )
• high number of immature Sertoli cells

cellular
azoospermia ( J:198499 )
• devoid of mature spermatozoa
abnormal spermatocyte morphology ( J:198499 )
• irregular primary spermatocyte localization




Genotype
MGI:3050574
hm2
Allelic
Composition		 Akap9mei2-5/Akap9mei2-5
Genetic
Background		 involves: 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap9mei2-5 mutation (0 available); any Akap9 mutation (181 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
arrest of male meiosis ( J:86161 )
• meiotic arrest at pachytene stage
• some post meiotic spermatids present
abnormal testis morphology ( J:86161 )
• testis size varies with genetic background
male infertility ( J:86161 )
• sterility in males only

endocrine/exocrine glands
abnormal testis morphology ( J:86161 )
• testis size varies with genetic background

cellular
arrest of male meiosis ( J:86161 )
• meiotic arrest at pachytene stage
• some post meiotic spermatids present




Genotype
MGI:5516021
ht3
Allelic
Composition		 Akap9mei2-5/Akap9repro12
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akap9mei2-5 mutation (0 available); any Akap9 mutation (181 available)
Akap9repro12 mutation (0 available); any Akap9 mutation (181 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatogenesis ( J:198499 )
• severely impaired
azoospermia ( J:198499 )
• devoid of mature spermatozoa
arrest of spermatogenesis ( J:198499 )
• no evidence of spermiogenesis
• mice are phenotypically indistinguishable from either single homozygote

cellular
azoospermia ( J:198499 )
• devoid of mature spermatozoa




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory