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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Iqcgesgd12d
male sterility, John Schimenti
MGI:3050608
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Iqcgesgd12d/Iqcgesgd12d involves: C3HeB/FeJ * C57BL/6 MGI:3050616
hm2
 		Iqcgesgd12d/Iqcgesgd12d involves: C57BL/6 MGI:5696799
ht3
 		Iqcgesgd12d/Iqcgtm1b(EUCOMM)Wtsi involves: C57BL/6 * C57BL/6N * FVB/NJ MGI:5696800


Genotype
MGI:3050616
hm1
Allelic
Composition		 Iqcgesgd12d/Iqcgesgd12d
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iqcgesgd12d mutation (0 available); any Iqcg mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
asthenozoospermia ( J:92463 )
• very low motility
abnormal spermatogenesis ( J:86161 )
• round spermatids produced
• acrosome and sperm head develop
azoospermia ( J:86161 )
• few intact epididymal spermatozoa present
oligozoospermia ( J:92463 )
• very low epididymal sprem concentration
teratozoospermia ( J:92463 )
• predominantly sperm heads without tails or with short tails
male infertility ( J:86161 , J:92463 )
• sterility in males only (J:86161)
(J:92463)

cellular
azoospermia ( J:86161 )
• few intact epididymal spermatozoa present
oligozoospermia ( J:92463 )
• very low epididymal sprem concentration
teratozoospermia ( J:92463 )
• predominantly sperm heads without tails or with short tails
asthenozoospermia ( J:92463 )
• very low motility




Genotype
MGI:5696799
hm2
Allelic
Composition		 Iqcgesgd12d/Iqcgesgd12d
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iqcgesgd12d mutation (0 available); any Iqcg mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:218515 )
N
• acrosomal cap formation is apparently normal in sperm
azoospermia ( J:218515 )
• spermatozoa lacking in the epididymus
abnormal spermiogenesis ( J:218515 )
• elongated spermatids lacking tails released into seminiferous tubules
• unattached sperm tails found in the lumen of seminiferous tubules
• sperm with tails tend to be non-motile
• sperm with tails have abnormal heads

cellular
azoospermia ( J:218515 )
• spermatozoa lacking in the epididymus




Genotype
MGI:5696800
ht3
Allelic
Composition		 Iqcgesgd12d/Iqcgtm1b(EUCOMM)Wtsi
Genetic
Background		 involves: C57BL/6 * C57BL/6N * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Iqcgesgd12d mutation (0 available); any Iqcg mutation (32 available)
Iqcgtm1b(EUCOMM)Wtsi mutation (0 available); any Iqcg mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:218515 )
N
• acrosomal cap formation is apparently normal in sperm
azoospermia ( J:218515 )
• spermatozoa lacking in the epididymus
• lack any motile sperm
abnormal spermiogenesis ( J:218515 )
• elongated spermatids lacking tails released into seminiferous tubules
• unattached sperm tails found in the lumen of seminiferous tubules
• sperm with tails are non-motile
• sperm with tails have abnormal heads

cellular
azoospermia ( J:218515 )
• spermatozoa lacking in the epididymus
• lack any motile sperm




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory