Phenotypes associated with this allele

• Allele Symbol: Dab1^tm4Cpr
• Allele Name: targeted mutation 1, Jonathan A Cooper
• Allele ID: MGI:3050637
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dab1^tm4Cpr/Dab1^tm4Cpr	involves: 129/Sv * C57BL/6	MGI:3050784
ht2	Dab1^tm1Cpr/Dab1^tm4Cpr	involves: 129/Sv * C57BL/6	MGI:3050789
cx3	Dab1^tm1Cpr/Dab1^tm4Cpr Reln^rl/Reln^+	involves: 129/Sv * C3HeB/Fe * C57BL/6	MGI:3050790

Genotype
MGI:3050784

hm1

• Allelic Composition: Dab1^tm4Cpr/Dab1^tm4Cpr
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:91679 )

• homozygotes are viable and fertile and no defects are seen in the cortex, hippocampus, cerebellum, or other brain regions

Genotype
MGI:3050789

ht2

• Allelic Composition: Dab1^tm1Cpr/Dab1^tm4Cpr
• Genetic Background: involves: 129/Sv * C57BL/6

nervous system

abnormal cortical marginal zone morphology ( J:91679 )

• the marginal zone of the cortex is reduced compared to mice heterozygous for either allele alone

• at E16.5 cortical plate neurons are more superficial than normal

Genotype
MGI:3050790

cx3

• Allelic Composition: Dab1^tm1Cpr/Dab1^tm4Cpr; Reln^rl/Reln⁺
• Genetic Background: involves: 129/Sv * C3HeB/Fe * C57BL/6

nervous system

abnormal cortical marginal zone morphology ( J:91679 )

• the marginal zone of the cortex is reduced, similar to compound heterozygous mice wild-type for Reln

abnormal hippocampus morphology ( J:91679 )

• the hippocampus is subtly disorganized in the CA2/3 region compared to mice heterozygous for Dab1^tm1Cpr and Reln^rl