All Phenotypes swm2 MGI Mouse

immotile sperm ( J:117563 )

• immobile sperm

abnormal spermatogenesis ( J:86161 )

• abnormal development of sperm heads and flagella

oligozoospermia ( J:86161 , J:117563 )

• nearly aspermic (J:86161)

• disorganized masses of cell bodies near the lumen of seminiferous tubules (J:86161)

• sperm concentration is (0.42 +/- 0.66) x 10⁶ sperm/ml (J:117563)

• however, testes and seminal vesicle weights are similar to wild-type (J:117563)

teratozoospermia ( J:117563 )

• many sperm lack heads or tails and the remainder have abnormal head and/or tail morphology

• partial separation between the head and neck in rare cases

abnormal sperm midpiece morphology ( J:117563 )

• a short and discontinuous midpiece is observed

abnormal sperm mitochondrial sheath morphology ( J:117563 )

• misaligned mitochondrial sheaths are observed

• mitochondria are frequently dispersed in the cytoplasmic droplet or irregularly clustered around the axoneme

abnormal sperm principal piece morphology ( J:117563 )

• incomplete differentiation of the principal tail piece

absent sperm flagellum ( J:86161 )

• most sperm lack flagella; however, those with flagella are capable of some movement

short sperm flagellum ( J:117563 )

• tail elongation is impaired

abnormal sperm nucleus morphology ( J:117563 )

• abnormal hammerhead nuclear shapes are observed

absent sperm head ( J:117563 )

• many sperm lack heads

abnormal spermatid morphology ( J:117563 )

• some spermatids display abnormal hammerhead nuclear shapes and tail elongation is impaired with no completely differentiated principal tail pieces detected

• most condensed spermatids display incorrectly aligned mitochondrial sheaths and frequently have mitochondria dispersed in the cytoplasmic droplet or irregularly clustered around the axoneme

male infertility ( J:86161 , J:117563 )

• sterility in males only (J:86161)

(J:117563)

impaired fertilization ( J:117563 )

• sperm fail to fertilize oocytes in in vitro fertilization tests