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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pim2tm1Brn
targeted mutation 1, Anton Berns
MGI:3050662
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pim2tm1Brn/Pim2tm1Brn involves: 129P/Ola * FVB/N MGI:3051565
cx2
 		Pim1tm1Pwl/Pim1tm1Pwl
Pim2tm1Brn/Pim2tm1Brn
Pim3tm1Brn/Pim3tm1Brn 		involves: 129P/Ola * FVB/N MGI:3051567


Genotype
MGI:3051565
hm1
Allelic
Composition		 Pim2tm1Brn/Pim2tm1Brn
Genetic
Background		 involves: 129P/Ola * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pim2tm1Brn mutation (0 available); any Pim2 mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:91592 )
• T cell proliferation is reduced in response to suboptimal levels of alphaCD3 and human IL2

hematopoietic system
decreased T cell proliferation ( J:91592 )
• T cell proliferation is reduced in response to suboptimal levels of alphaCD3 and human IL2

cellular
decreased T cell proliferation ( J:91592 )
• T cell proliferation is reduced in response to suboptimal levels of alphaCD3 and human IL2




Genotype
MGI:3051567
cx2
Allelic
Composition		 Pim1tm1Pwl/Pim1tm1Pwl
Pim2tm1Brn/Pim2tm1Brn
Pim3tm1Brn/Pim3tm1Brn
Genetic
Background		 involves: 129P/Ola * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pim1tm1Pwl mutation (0 available); any Pim1 mutation (16 available)
Pim2tm1Brn mutation (0 available); any Pim2 mutation (7 available)
Pim3tm1Brn mutation (0 available); any Pim3 mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased birth body size ( J:91592 )
• neonates are smaller compared to wild-type and littermates that are not homozygous for at least one of the loci
postnatal growth retardation ( J:91592 )
• mutants are about 30% smaller compared to wild-type and littermates that are not homozygous at at least one of the loci
• all organs, except for the thymus, are decreased in size in proportion to the reduced body size as a result of a decrease in cell number

hematopoietic system
decreased B cell proliferation ( J:91592 )
• B cell proliferation in response to IL-7 is significantly impaired in the bone marrow
decreased T cell proliferation ( J:91592 )
• T cell proliferation is reduced in response to suboptimal levels of alphaCD3 and IL2
increased early pro-B cell number ( J:91592 )
• the fraction of pre-pro-B cells is increased in the bone marrow
decreased pro-B cell number ( J:91592 )
• the fraction of late pro-B cells is slightly decreased
decreased megakaryocyte cell number ( J:91592 )
• fewer and hypoproliferative megakaryocytes are seen in spleen sections
abnormal proerythroblast morphology ( J:91592 )
• the erythroid progenitor fraction in the spleen is increased
increased erythrocyte cell number ( J:91592 )
• a slight increase in erythrocyte numbers is seen without an increase in hematocrit
• the number of mature erthrocytes is also increased in the spleen
decreased mean corpuscular volume ( J:91592 )
• mean erythrocyte cell volume is decreased
decreased B cell number ( J:91592 )
• the fraction of splenic B cell is reduced about 25% at 8 weeks but returns to normal by 20 weeks
decreased pre-B cell number ( J:91592 )
• the fraction of pre-B cells especially of late pre-B cells is decreased in the bone marrow

immune system
decreased B cell proliferation ( J:91592 )
• B cell proliferation in response to IL-7 is significantly impaired in the bone marrow
decreased T cell proliferation ( J:91592 )
• T cell proliferation is reduced in response to suboptimal levels of alphaCD3 and IL2
increased early pro-B cell number ( J:91592 )
• the fraction of pre-pro-B cells is increased in the bone marrow
decreased pro-B cell number ( J:91592 )
• the fraction of late pro-B cells is slightly decreased
decreased B cell number ( J:91592 )
• the fraction of splenic B cell is reduced about 25% at 8 weeks but returns to normal by 20 weeks
decreased pre-B cell number ( J:91592 )
• the fraction of pre-B cells especially of late pre-B cells is decreased in the bone marrow

cellular
decreased B cell proliferation ( J:91592 )
• B cell proliferation in response to IL-7 is significantly impaired in the bone marrow
decreased T cell proliferation ( J:91592 )
• T cell proliferation is reduced in response to suboptimal levels of alphaCD3 and IL2




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12/17/2024
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