Phenotypes associated with this allele

• Allele Symbol: Hrh3^tm1Kot
• Allele Name: targeted mutation 1, Hidehito Kotani
• Allele ID: MGI:3050799
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hrh3^tm1Kot/Hrh3^tm1Kot	involves: 129X1/SvJ * C57BL/6N	MGI:3050800

Genotype
MGI:3050800

hm1

• Allelic Composition: Hrh3^tm1Kot/Hrh3^tm1Kot
• Genetic Background: involves: 129X1/SvJ * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:80824 )

• overall fat mass is increased and lean mass decreased

• increased white and brown fat deposition is seen in the ovarian/epididymal, mesenteric, and retroperitoneal fat pads

behavior/neurological

polyphagia ( J:80824 )

• increased daily food intake is seen

decreased locomotor activity ( J:80824 )

• total and dark-phase locomotor activity are significantly reduced

growth/size/body

increased susceptibility to weight gain ( J:80824 )

• significantly increased weight gain is seen at 4 weeks compared to wild-type

homeostasis/metabolism

increased circulating insulin level ( J:80824 )

• plasma insulin levels are increased however plasma glucose, thyroxine, free fatty acid. and cholesterol levels are normal

increased circulating leptin level ( J:80824 )

• plasma leptin is increased

decreased core body temperature ( J:80824 )

• core body temperature is slightly but consistently reduced

abnormal energy expenditure ( J:80824 )

• energy expenditure is reduced

decreased oxygen consumption ( J:80824 )

• basal and total oxygen consumption is reduced

insulin resistance ( J:80824 )

• following injection of insulin reduced glucose clearance is seen

decreased response to leptin ( J:80824 )