About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfat5tm1Snh
targeted mutation 1, Steffan N Ho
MGI:3050805
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nfat5tm1Snh/Nfat5tm1Snh involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3051135
ht2
 		Nfat5tm1Snh/Nfat5+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3051136


Genotype
MGI:3051135
hm1
Allelic
Composition		 Nfat5tm1Snh/Nfat5tm1Snh
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfat5tm1Snh mutation (0 available); any Nfat5 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:91482 )
• Background Sensitivity: with fewer than two generations of backcrossing to C57BL/6, embryos begin to die around E14.5
perinatal lethality, complete penetrance ( J:91482 )
• after more than 3 generations of backcrossing to C57BL/6, homozygous embryos are present at the expected frequency through E20.5 but die in the immediate perinatal period




Genotype
MGI:3051136
ht2
Allelic
Composition		 Nfat5tm1Snh/Nfat5+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfat5tm1Snh mutation (0 available); any Nfat5 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell proliferation ( J:91482 )
• proliferation of T cells is reduced in hypertonic and hyperosmotic conditions but not in isosmotic or isotonic conditions
thymus hypoplasia ( J:91482 )
• thymus cellularity is reduced by 40% compared to wild-type littermates
spleen hypoplasia ( J:91482 )
• spleen cellularity is reduced by 32% compared to wild-type littermates
abnormal immunoglobulin level ( J:91482 )
• antigen specific antibody production is reduced 44% compared to wild-type mice
decreased IgG level ( J:91482 )
• total serum IgG but not IgM levels are reduced by 35%

immune system
decreased T cell proliferation ( J:91482 )
• proliferation of T cells is reduced in hypertonic and hyperosmotic conditions but not in isosmotic or isotonic conditions
thymus hypoplasia ( J:91482 )
• thymus cellularity is reduced by 40% compared to wild-type littermates
spleen hypoplasia ( J:91482 )
• spleen cellularity is reduced by 32% compared to wild-type littermates
abnormal immunoglobulin level ( J:91482 )
• antigen specific antibody production is reduced 44% compared to wild-type mice
decreased IgG level ( J:91482 )
• total serum IgG but not IgM levels are reduced by 35%

endocrine/exocrine glands
thymus hypoplasia ( J:91482 )
• thymus cellularity is reduced by 40% compared to wild-type littermates

cellular
decreased T cell proliferation ( J:91482 )
• proliferation of T cells is reduced in hypertonic and hyperosmotic conditions but not in isosmotic or isotonic conditions




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory