Phenotypes associated with this allele

• Allele Symbol: Fhl5^tm1Saco
• Allele Name: targeted mutation 1, Paolo Sassone-Corsi
• Allele ID: MGI:3050807
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fhl5^tm1Saco/Fhl5^tm1Saco	involves: 129S2/SvPas * C57BL/6	MGI:3050891

Genotype
MGI:3050891

hm1

• Allelic Composition: Fhl5^tm1Saco/Fhl5^tm1Saco
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal morphology of Fhl5^tm1Saco/Fhl5^tm1Saco mice mature germ cells.

endocrine/exocrine glands

small testis ( J:91483 )

♂ • a 10-15% size reduction in about 10% of males

reproductive system

asthenozoospermia ( J:91483 )

♂ • spermatozoa are less motile

abnormal gametogenesis ( J:91483 )

oligozoospermia ( J:91483 )

♂ • only about 35% as much sperm in epididymis as found in wild-type mice

teratozoospermia ( J:91483 )

♂ • mutant epididymal sperm exhibit many structural abnormalities

hairpin sperm flagellum ( J:91483 )

♂ • 80% of mutant epididymal sperm have tails with hairpin loops, exhibiting a 180 bend in the principal piece, as opposed to 15% in wild-type

♂ • in some cases, the bend in the tail is adjacent to the nucleus

abnormal sperm head morphology ( J:91483 )

♂ • ~50% of male homozygotes exhibit an exceptionally high number of spermatozoa with abnormally shaped heads

♂ • the back of the sperm head is frequently malformed and more angular in shape

♂ • some mutant heads also display a very short apex

abnormal acrosome morphology ( J:91483 )

♂ • acrosomal malformations with elongated projections are observed

detached acrosome ( J:91483 )

♂ • many sperm cells exhibit a detached acrosome

abnormal sperm nucleus morphology ( J:91483 )

♂ • aberrantly shaped sperm heads display defects in the compaction of nuclear chromatin

♂ • nuclear vacuoles and severe nuclear malformations are observed

abnormal male reproductive system morphology ( J:91483 )

♂

small testis ( J:91483 )

♂ • a 10-15% size reduction in about 10% of males

abnormal cauda epididymis morphology ( J:91483 )

♂ • cauda epididymis is always smaller and more transparent than wild-type

delayed male fertility ( J:91483 )

• male fertility is apparently delayed about 1 month but otherwise normal

cellular

oligozoospermia ( J:91483 )

♂ • only about 35% as much sperm in epididymis as found in wild-type mice

teratozoospermia ( J:91483 )

♂ • mutant epididymal sperm exhibit many structural abnormalities

hairpin sperm flagellum ( J:91483 )

♂ • 80% of mutant epididymal sperm have tails with hairpin loops, exhibiting a 180 bend in the principal piece, as opposed to 15% in wild-type

♂ • in some cases, the bend in the tail is adjacent to the nucleus

abnormal sperm head morphology ( J:91483 )

♂ • ~50% of male homozygotes exhibit an exceptionally high number of spermatozoa with abnormally shaped heads

♂ • the back of the sperm head is frequently malformed and more angular in shape

♂ • some mutant heads also display a very short apex

abnormal acrosome morphology ( J:91483 )

♂ • acrosomal malformations with elongated projections are observed

detached acrosome ( J:91483 )

♂ • many sperm cells exhibit a detached acrosome

abnormal sperm nucleus morphology ( J:91483 )

♂ • aberrantly shaped sperm heads display defects in the compaction of nuclear chromatin

♂ • nuclear vacuoles and severe nuclear malformations are observed

asthenozoospermia ( J:91483 )

♂ • spermatozoa are less motile