All Phenotypes Met<tm2Cbm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Met^tm2Cbm
targeted mutation 2, Carmen Birchmeier
MGI:3050810

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Met^tm2Cbm/Met^tm2.1Cbm Tg(Mx1-cre)1Cgn/?	involves: C57BL/6 * CBA	MGI:3050982

Allelic Composition	Met^tm2Cbm/Met^tm2.1Cbm Tg(Mx1-cre)1Cgn/?
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Met^tm2.1Cbm mutation (0 available); any Met mutation (83 available)
Met^tm2Cbm mutation (0 available); any Met mutation (83 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

microvesicular hepatic steatosis ( J:91484 )

• liver was normal at 3 weeks after transgene induction

• 6 months after transgene induction, liver contained an accumulation of small lipid droplets (microvesicular steatosis) but no fibrosis

impaired liver regeneration ( J:91484 )

• regeneration of the liver after partial hepatectomy is impaired

• growth factors in the blood such as HGF/SF and Il6 peak a little later than in wild-type mice (6-12 hours as opposed to 6 hours postoperatively)

• growth factor levels remain elevated longer (still high at 46 hours postoperative)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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