Phenotypes associated with this allele

• Allele Symbol: Met^tm2.1Cbm
• Allele Name: targeted mutation 2.1, Carmen Birchmeier
• Allele ID: MGI:3050811
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Met^tm2Cbm/Met^tm2.1Cbm Tg(Mx1-cre)1Cgn/?	involves: C57BL/6 * CBA	MGI:3050982

Genotype
MGI:3050982

cn1

• Allelic Composition: Met^tm2Cbm/Met^tm2.1Cbm; Tg(Mx1-cre)1Cgn/?
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

microvesicular hepatic steatosis ( J:91484 )

• liver was normal at 3 weeks after transgene induction

• 6 months after transgene induction, liver contained an accumulation of small lipid droplets (microvesicular steatosis) but no fibrosis

impaired liver regeneration ( J:91484 )

• regeneration of the liver after partial hepatectomy is impaired

• growth factors in the blood such as HGF/SF and Il6 peak a little later than in wild-type mice (6-12 hours as opposed to 6 hours postoperatively)

• growth factor levels remain elevated longer (still high at 46 hours postoperative)