Phenotypes associated with this allele

• Allele Symbol: Pparg^tm1Yec
• Allele Name: targeted mutation 1, Yuqing E Chen
• Allele ID: MGI:3050813
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pparg^tm1Yec/Pparg^tm1Yec	involves: 129S4/SvJae * C57BL/6	MGI:3051007

Genotype
MGI:3051007

hm1

• Allelic Composition: Pparg^tm1Yec/Pparg^tm1Yec
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal brown adipose tissue morphology ( J:91479 )

• the brown fat in homozygous mutants is darker compared to wild-type mice

decreased brown fat cell lipid droplet size ( J:91479 )

• the size of lipid droplets in brown fat adipocytes are reduced compared to wild-type mice

decreased brown fat lipid droplet number ( J:91479 )

• the number of lipid droplets in brown fat adipocytes are reduced compared to wild-type mice

decreased gonadal fat pad weight ( J:91479 )

• the gonadal fat pad weight is reduced by 74% compared to wild-type

decreased inguinal fat pad weight ( J:91479 )

• the inguinal fat pad weight is reduced by 25% compared to wild-type

decreased retroperitoneal fat pad weight ( J:91479 )

• the retroperitoneal fat pad weight is reduced by 37% compared to wild-type

abnormal white adipose tissue morphology ( J:91479 )

• adipocytes are decreased in size about 2.6 fold, adipocyte sizes are more heterogeneous than in wild-type mice, and the overall number of adipocytes is reduced

decreased white adipose tissue amount ( J:91479 )

• on a normal diet the overall white fat weight is reduced compared to wild-type

• on a high fat diet the overall white fat weight does not increase unlike in wild-type mice

decreased white fat cell number ( J:91479 )

• the overall number of adipocytes is reduced

decreased white fat cell size ( J:91479 )

• adipocytes are decreased in size about 2.6 fold

• adipocyte sizes are more heterogeneous than in wild-type mice

abnormal white adipose tissue physiology ( J:91479 )

growth/size/body

decreased body weight ( J:91479 )

• homozygous mice are protected against excess weight gain when on a high fat diet

homeostasis/metabolism

decreased circulating leptin level ( J:91479 )

• circulating leptin levels are decreased

insulin resistance ( J:91479 )

• homozygous mutant males but not females are resistant to the glucose lowering effect of exogenous insulin

decreased circulating adiponectin level ( J:91479 )

• circulating adiponectin levels are decreased

liver/biliary system

liver/biliary system phenotype ( J:91479 )

N • the liver is normal in appearance unlike in mice homozygous for Pparg^tm1Rev that accumulate fat in the liver