All Phenotypes Tg(MMTV-Erbb2)NF1Mul MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(MMTV-Erbb2)NF1Mul/0	FVB/N-Tg(MMTV-Erbb2)NF1Mul	MGI:3785834
tg2	Tg(MMTV-Erbb2)NF1Mul/0	involves: CD-1 * FVB/N	MGI:3785827
tg3	Tg(MMTV-Erbb2)NF1Mul/0	involves: FVB/N	MGI:3785826

Allelic Composition	Tg(MMTV-Erbb2)NF1Mul/0
Genetic Background	FVB/N-Tg(MMTV-Erbb2)NF1Mul

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:48632 )

• mice develop stochastic solid mammary gland tumors

• female mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:48632 )

• mice develop stochastic solid mammary gland tumors

• female mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

integument

increased mammary adenocarcinoma incidence ( J:48632 )

• mice develop stochastic solid mammary gland tumors

• female mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

Allelic Composition	Tg(MMTV-Erbb2)NF1Mul/0
Genetic Background	involves: CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:48632 )

• mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:48632 )

• mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

integument

increased mammary adenocarcinoma incidence ( J:48632 )

• mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal epididymis epithelium morphology ( J:48632 )

• male mice exhibit bilateral papillary hyperplasia that protrudes into the lumen of the epididymis

reduced male fertility ( J:48632 )

neoplasm

increased mammary adenocarcinoma incidence ( J:48632 )

• at 8 weeks, mice exhibit multiple hyperplastic and dysplastic nodules of the mammary epithelium infiltrating the entire mammary fat pad

• at 95 days, female mice exhibit multiple mammary tumors female mice develop tumors by 89 days and male mice by 114 days

• female mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

endocrine/exocrine glands

abnormal parotid gland morphology ( J:48632 )

• male mice exhibit bilateral hypertrophic serous glands with large quantities of intracytoplasmic secretions and the intermingling of hyperplastic mucous gland epithelium

increased parotid gland size ( J:48632 )

• the parotid gland of male mice weighs five times more than in wild-type mice

increased mammary adenocarcinoma incidence ( J:48632 )

• at 8 weeks, mice exhibit multiple hyperplastic and dysplastic nodules of the mammary epithelium infiltrating the entire mammary fat pad

• at 95 days, female mice exhibit multiple mammary tumors female mice develop tumors by 89 days and male mice by 114 days

• female mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

behavior/neurological

abnormal nursing ( J:48632 )

• females fail to nurse

digestive/alimentary system

abnormal parotid gland morphology ( J:48632 )

• male mice exhibit bilateral hypertrophic serous glands with large quantities of intracytoplasmic secretions and the intermingling of hyperplastic mucous gland epithelium

increased parotid gland size ( J:48632 )

• the parotid gland of male mice weighs five times more than in wild-type mice

integument

increased mammary adenocarcinoma incidence ( J:48632 )

• at 8 weeks, mice exhibit multiple hyperplastic and dysplastic nodules of the mammary epithelium infiltrating the entire mammary fat pad

• at 95 days, female mice exhibit multiple mammary tumors female mice develop tumors by 89 days and male mice by 114 days

• female mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24