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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(MMTV-Erbb2)NF1Mul
transgene insertion NF1, William Muller
MGI:3050869
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(MMTV-Erbb2)NF1Mul/0 FVB/N-Tg(MMTV-Erbb2)NF1Mul MGI:3785834
tg2
Tg(MMTV-Erbb2)NF1Mul/0 involves: CD-1 * FVB/N MGI:3785827
tg3
Tg(MMTV-Erbb2)NF1Mul/0 involves: FVB/N MGI:3785826


Genotype
MGI:3785834
tg1
Allelic
Composition
Tg(MMTV-Erbb2)NF1Mul/0
Genetic
Background
FVB/N-Tg(MMTV-Erbb2)NF1Mul
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice develop stochastic solid mammary gland tumors
• female mice exhibit diffuse, polyclonal tumor masses
• tumor morphogenesis corresponds to transgene expression

endocrine/exocrine glands
• mice develop stochastic solid mammary gland tumors
• female mice exhibit diffuse, polyclonal tumor masses
• tumor morphogenesis corresponds to transgene expression

integument
• mice develop stochastic solid mammary gland tumors
• female mice exhibit diffuse, polyclonal tumor masses
• tumor morphogenesis corresponds to transgene expression




Genotype
MGI:3785827
tg2
Allelic
Composition
Tg(MMTV-Erbb2)NF1Mul/0
Genetic
Background
involves: CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice exhibit diffuse, polyclonal tumor masses
• tumor morphogenesis corresponds to transgene expression

endocrine/exocrine glands
• mice exhibit diffuse, polyclonal tumor masses
• tumor morphogenesis corresponds to transgene expression

integument
• mice exhibit diffuse, polyclonal tumor masses
• tumor morphogenesis corresponds to transgene expression




Genotype
MGI:3785826
tg3
Allelic
Composition
Tg(MMTV-Erbb2)NF1Mul/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• male mice exhibit bilateral papillary hyperplasia that protrudes into the lumen of the epididymis

neoplasm
• at 8 weeks, mice exhibit multiple hyperplastic and dysplastic nodules of the mammary epithelium infiltrating the entire mammary fat pad
• at 95 days, female mice exhibit multiple mammary tumors female mice develop tumors by 89 days and male mice by 114 days
• female mice exhibit diffuse, polyclonal tumor masses
• tumor morphogenesis corresponds to transgene expression

endocrine/exocrine glands
• male mice exhibit bilateral hypertrophic serous glands with large quantities of intracytoplasmic secretions and the intermingling of hyperplastic mucous gland epithelium
• the parotid gland of male mice weighs five times more than in wild-type mice
• at 8 weeks, mice exhibit multiple hyperplastic and dysplastic nodules of the mammary epithelium infiltrating the entire mammary fat pad
• at 95 days, female mice exhibit multiple mammary tumors female mice develop tumors by 89 days and male mice by 114 days
• female mice exhibit diffuse, polyclonal tumor masses
• tumor morphogenesis corresponds to transgene expression

behavior/neurological
• females fail to nurse

digestive/alimentary system
• male mice exhibit bilateral hypertrophic serous glands with large quantities of intracytoplasmic secretions and the intermingling of hyperplastic mucous gland epithelium
• the parotid gland of male mice weighs five times more than in wild-type mice

integument
• at 8 weeks, mice exhibit multiple hyperplastic and dysplastic nodules of the mammary epithelium infiltrating the entire mammary fat pad
• at 95 days, female mice exhibit multiple mammary tumors female mice develop tumors by 89 days and male mice by 114 days
• female mice exhibit diffuse, polyclonal tumor masses
• tumor morphogenesis corresponds to transgene expression





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory