All Phenotypes Tg(MMTV-Erbb2)NK1Mul MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(MMTV-Erbb2)NK1Mul
transgene insertion NK1, William Muller
MGI:3050871

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ccnd1^tm1Wbg/Ccnd1^tm5.1Pisc Tg(CAG-cre/Esr1*)5Amc/0 Tg(MMTV-Erbb2)NK1Mul/0	involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N	MGI:5468352
cx2	Akt3^tm1Mbb/Akt3^tm1Mbb Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul	involves: 129 * C57BL/6 * FVB/N	MGI:3804003
cx3	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul	involves: 129 * C57BL/6 * FVB/N	MGI:3804004
cx4	Akt1^Gt1Pnt/Akt1^Gt1Pnt Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul	involves: 129 * C57BL/6 * FVB/N	MGI:3804005
cx5	Esr1^tm1Ksk/Esr1^tm1Ksk Tg(MMTV-Erbb2)NK1Mul/0	involves: 129P2/OlaHsd * C57BL/6J * FVB/N	MGI:4438040
cx6	Ccnd1^tm4Pisc/Ccnd1^tm4Pisc Tg(MMTV-Erbb2)NK1Mul/0	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:4421802
cx7	Ccnd1^tm1Phin/Ccnd1^tm1Phin Tg(MMTV-Erbb2)NK1Mul/0	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:3614895
cx8	Cdc25a^tm1Kiyo/Cdc25a⁺ Tg(MMTV-Erbb2)NK1Mul/?	involves: 129/Sv * C57BL/6 * FVB/N	MGI:3718003
tg9	Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul	involves: 129 * C57BL/6 * FVB/N	MGI:3804001
tg10	Tg(MMTV-Erbb2)NK1Mul/0	FVB/N-Tg(MMTV-Erbb2)NK1Mul	MGI:5538583
tg11	Tg(MMTV-Erbb2)NK1Mul/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:4438041
tg12	Tg(MMTV-Erbb2)NK1Mul/0	involves: FVB/N	MGI:3785797

Allelic Composition	Ccnd1^tm1Wbg/Ccnd1^tm5.1Pisc Tg(CAG-cre/Esr1*)5Amc/0 Tg(MMTV-Erbb2)NK1Mul/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm1Wbg mutation (2 available); any Ccnd1 mutation (22 available)
Ccnd1^tm5.1Pisc mutation (0 available); any Ccnd1 mutation (22 available)
Tg(CAG-cre/Esr1*)5Amc mutation (10 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased tumor growth/size ( J:192032 )

• tamoxifen-treatment halts cancer progression and lowers tumor burden with increased senescence of tumor cells compared to in control mice

Allelic Composition	Akt3^tm1Mbb/Akt3^tm1Mbb Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 54 weeks of age which is slightly but not significantly later than in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

integument

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 54 weeks of age which is slightly but not significantly later than in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 54 weeks of age which is slightly but not significantly later than in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

Allelic Composition	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1.1Mbb mutation (2 available); any Akt2 mutation (53 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 45 weeks of age which is significantly earlier than occurs in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 45 weeks of age which is significantly earlier than occurs in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

integument

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 45 weeks of age which is significantly earlier than occurs in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

Allelic Composition	Akt1^Gt1Pnt/Akt1^Gt1Pnt Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^Gt1Pnt mutation (0 available); any Akt1 mutation (34 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:117336 )

• 10% of female virgin mice develop mammary tumors by 60 weeks of age which is a much lower incidence than occurs in mice carrying the transgene on a wild-type background

• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung is slightly enhanced in these mice

integument

increased mammary adenocarcinoma incidence ( J:117336 )

• 10% of female virgin mice develop mammary tumors by 60 weeks of age which is a much lower incidence than occurs in mice carrying the transgene on a wild-type background

• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung is slightly enhanced in these mice

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:117336 )

• 10% of female virgin mice develop mammary tumors by 60 weeks of age which is a much lower incidence than occurs in mice carrying the transgene on a wild-type background

• tumor growth in mammary glands is significantly slower than is found in transgenic mice on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung is slightly enhanced in these mice

Allelic Composition	Esr1^tm1Ksk/Esr1^tm1Ksk Tg(MMTV-Erbb2)NK1Mul/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1^tm1Ksk mutation (2 available); any Esr1 mutation (68 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:76653 )

increased tumor latency ( J:76653 )

• mice display 50% tumor incidence at 105 weeks of age compared to 52 weeks of age in transgenic mice wild-type for Esr1

• increasing progesterone levels accelerates tumor development

endocrine/exocrine glands

abnormal mammary gland development ( J:76653 )

• rudimentary mammary gland that fails to develop beyond the prepubertal stage

• however, duct structure is not different from homozygous null mice not carrying the transgene

increased mammary gland tumor incidence ( J:76653 )

integument

abnormal mammary gland development ( J:76653 )

• rudimentary mammary gland that fails to develop beyond the prepubertal stage

• however, duct structure is not different from homozygous null mice not carrying the transgene

increased mammary gland tumor incidence ( J:76653 )

Allelic Composition	Ccnd1^tm4Pisc/Ccnd1^tm4Pisc Tg(MMTV-Erbb2)NK1Mul/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm4Pisc mutation (0 available); any Ccnd1 mutation (22 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:156591 )

• 50% of mice develop tumors by about 45 weeks, same rate of occurrence as transgene alone

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:156591 )

• 50% of mice develop tumors by about 45 weeks, same rate of occurrence as transgene alone

integument

increased mammary adenocarcinoma incidence ( J:156591 )

• 50% of mice develop tumors by about 45 weeks, same rate of occurrence as transgene alone

Allelic Composition	Ccnd1^tm1Phin/Ccnd1^tm1Phin Tg(MMTV-Erbb2)NK1Mul/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccnd1^tm1Phin mutation (0 available); any Ccnd1 mutation (22 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased mammary gland tumor incidence ( J:105045 )

• resistant to Erbb2-induced breast cancers

integument

decreased mammary gland tumor incidence ( J:105045 )

• resistant to Erbb2-induced breast cancers

endocrine/exocrine glands

decreased mammary gland tumor incidence ( J:105045 )

• resistant to Erbb2-induced breast cancers

Allelic Composition	Cdc25a^tm1Kiyo/Cdc25a⁺ Tg(MMTV-Erbb2)NK1Mul/?
Genetic Background	involves: 129/Sv * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdc25a^tm1Kiyo mutation (0 available); any Cdc25a mutation (34 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased incidence of induced tumors ( J:123144 )

• mice develop tumors at a latency of 32 weeks compared to 23 weeks in Tg(MMTV-Erbb2)NK1Mul transgenic mice

• mice do not develop hyperplastic nodules in mammary glands as do Tg(MMTV-Erbb2)NK1Mul transgenic mice

cellular

decreased cell proliferation ( J:123144 )

• fewer cells are in S-phase and proliferation is decreased compared to in Tg(MMTV-Erbb2)NK1Mul transgenic mice

Allelic Composition	Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:117336 )

• all female virgin mice develop cancer tumors in the breast by 45 weeks of age

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:117336 )

• all female virgin mice develop cancer tumors in the breast by 45 weeks of age

integument

increased mammary adenocarcinoma incidence ( J:117336 )

• all female virgin mice develop cancer tumors in the breast by 45 weeks of age

Allelic Composition	Tg(MMTV-Erbb2)NK1Mul/0
Genetic Background	FVB/N-Tg(MMTV-Erbb2)NK1Mul

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:67457 )

• about 20% of mutants develop mammary tumors by the 25th week of age, and by the 30th week, tumor incidence increases to 83%

• high dose of flaxseed oil (with a an omega6:omega3 fatty acid ratio of about 1) results in some delay in the growth of mammary tumors, however low and mid doses with omega6:omega3 ratios of 7.7 and 3.1 enhance tumor development

• melatonin treatment delays the appearance of palpable tumors

• combination of both flaxseed oil and melatonin results in a slight delay of tumor development, similar that seen with melatonin only

integument

increased mammary gland tumor incidence ( J:67457 )

• about 20% of mutants develop mammary tumors by the 25th week of age, and by the 30th week, tumor incidence increases to 83%

• melatonin treatment delays the appearance of palpable tumors

• combination of both flaxseed oil and melatonin results in a slight delay of tumor development, similar that seen with melatonin only

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:67457 )

• about 20% of mutants develop mammary tumors by the 25th week of age, and by the 30th week, tumor incidence increases to 83%

• melatonin treatment delays the appearance of palpable tumors

• combination of both flaxseed oil and melatonin results in a slight delay of tumor development, similar that seen with melatonin only

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:67457

Allelic Composition	Tg(MMTV-Erbb2)NK1Mul/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:76653 )

increased tumor latency ( J:76653 )

• Background Sensitivity: mice display 50% tumor incidence at 52 weeks of age compared to 25 weeks of age in mice on an FVB/N background

• mice ovariectomized at 18-20 days of age, but not those ovariectomized at 16-20 weeks of age, display a further delay in tumor onset (50% incidence at 62 weeks of age)

• breeding females accelerates tumor development (50% incidence at 32 weeks of age)

reproductive system

reproductive system phenotype ( J:76653 )

N	• unlike in previous reports, mammary gland ductal structure is not different from controls prior to the onset of tumor formation

integument

increased mammary gland tumor incidence ( J:76653 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:76653 )

Allelic Composition	Tg(MMTV-Erbb2)NK1Mul/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:48632 )

• female mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

• tumors are more sparsely distributed than in other lines of the transgene

integument

increased mammary adenocarcinoma incidence ( J:48632 )

• female mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

• tumors are more sparsely distributed than in other lines of the transgene

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:48632 )

• female mice exhibit diffuse, polyclonal tumor masses

• tumor morphogenesis corresponds to transgene expression

• tumors are more sparsely distributed than in other lines of the transgene

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