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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tetO-Shh)1Jaw
transgene insertion 1, Jeffrey A Whitsett
MGI:3051146
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Shhtm1Amc/Shhtm1Amc
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-Shh)1Jaw/0 		involves: FVB/N MGI:3051585


Genotype
MGI:3051585
cx1
Allelic
Composition		 Shhtm1Amc/Shhtm1Amc
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-Shh)1Jaw/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shhtm1Amc mutation (1 available); any Shh mutation (48 available)
Tg(SFTPC-rtTA)5Jaw mutation (4 available)
Tg(tetO-Shh)1Jaw mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:91723 )
• mutants die shortly after birth even when doxycycline is administered throughout gestation

respiratory system
abnormal lung lobe morphology ( J:91723 )
• a significant increase in peripheral lung tissue and relatively normal branching morphogenesis are seen with doxycycline treatment; however, lobulation of the lungs is not restored
absent tracheal cartilage rings ( J:91723 )
• doxycycline treatment does not restore tracheal-bronchial cartilaginous ring formation

skeleton
absent tracheal cartilage rings ( J:91723 )
• doxycycline treatment does not restore tracheal-bronchial cartilaginous ring formation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory