About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rabgef1tm2Glli
targeted mutation 2, Stephen J Galli
MGI:3051238
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rabgef1tm2Glli/Rabgef1tm2Glli WBB6F1 MGI:3051407


Genotype
MGI:3051407
hm1
Allelic
Composition		 Rabgef1tm2Glli/Rabgef1tm2Glli
Genetic
Background		 WBB6F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rabgef1tm2Glli mutation (0 available); any Rabgef1 mutation (67 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:91790 )
• all died within the first 24 hours of life

immune system
increased interleukin-6 secretion ( J:91790 )
• increased IL-6 release in response to high affinity IgE receptor aggregation
increased tumor necrosis factor secretion ( J:91790 )
• increased TNF release in response to high affinity IgE receptor aggregation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory