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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ptcratm1Vbo
targeted mutation 1, Harald von Boehmer
MGI:3051255
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ptcratm1Vbo/Ptcratm1Vbo involves: 129P2/OlaHsd MGI:3805107
hm2
 		Ptcratm1Vbo/Ptcratm1Vbo involves: 129P2/OlaHsd * C57BL/6 MGI:3052043
cx3
 		H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo 		involves: 129P2/OlaHsd MGI:3807285
cx4
 		H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/? 		involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807286
cx5
 		Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
H2d/H2d
Ptcratm1Vbo/Ptcratm1Vbo
Tg(Tcrb)93Vbo/? 		involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807288
cx6
 		H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tg(TcraH-Y,TcrbH-Y)71Vbo/? 		involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807289


Genotype
MGI:3805107
hm1
Allelic
Composition		 Ptcratm1Vbo/Ptcratm1Vbo
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptcratm1Vbo mutation (0 available); any Ptcra mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased DN4 thymocyte number ( J:123569 )
• mice exhibit a decrease in DN4 T cells
increased DN3 thymocyte number ( J:123569 )
• mice exhibit an increase in DN3 T cells
abnormal double-positive T cell morphology ( J:123569 )
• increase in number relative Rpl22-deficient mice

hematopoietic system
decreased DN4 thymocyte number ( J:123569 )
• mice exhibit a decrease in DN4 T cells
increased DN3 thymocyte number ( J:123569 )
• mice exhibit an increase in DN3 T cells
abnormal double-positive T cell morphology ( J:123569 )
• increase in number relative Rpl22-deficient mice

endocrine/exocrine glands
decreased DN4 thymocyte number ( J:123569 )
• mice exhibit a decrease in DN4 T cells
increased DN3 thymocyte number ( J:123569 )
• mice exhibit an increase in DN3 T cells




Genotype
MGI:3052043
hm2
Allelic
Composition		 Ptcratm1Vbo/Ptcratm1Vbo
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptcratm1Vbo mutation (0 available); any Ptcra mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased double-negative T cell number ( J:91542 )
• the number of DN3 cells is increased 5 fold with 2 fold more proliferating DN3 cells but at least 3 fold fewer proliferating post-DN3 and DN4 cells compared to wild-type
arrested T cell differentiation ( J:91542 )
• a partial block in T cell development at the double negative 3 to double negative 4 transition is seen

immune system
increased double-negative T cell number ( J:91542 )
• the number of DN3 cells is increased 5 fold with 2 fold more proliferating DN3 cells but at least 3 fold fewer proliferating post-DN3 and DN4 cells compared to wild-type
arrested T cell differentiation ( J:91542 )
• a partial block in T cell development at the double negative 3 to double negative 4 transition is seen




Genotype
MGI:3807285
cx3
Allelic
Composition		 H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (30 available); any H2 mutation (282 available)
Ptcratm1Vbo mutation (0 available); any Ptcra mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte number ( J:131357 )
• thymocyte number is decreased by 10-fold compared to controls
decreased double-positive T cell number ( J:131357 )
• the percentage of DP thymocytes is severely reduced in the thymocytes
spleen hypoplasia ( J:131357 )
• spleen numbers are reduced by more than 4-fold

immune system
decreased thymocyte number ( J:131357 )
• thymocyte number is decreased by 10-fold compared to controls
decreased double-positive T cell number ( J:131357 )
• the percentage of DP thymocytes is severely reduced in the thymocytes
spleen hypoplasia ( J:131357 )
• spleen numbers are reduced by more than 4-fold

endocrine/exocrine glands
decreased thymocyte number ( J:131357 )
• thymocyte number is decreased by 10-fold compared to controls




Genotype
MGI:3807286
cx4
Allelic
Composition		 H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (30 available); any H2 mutation (282 available)
Ptcratm1Vbo mutation (0 available); any Ptcra mutation (16 available)
Tcra/Tcrdtm1.1(Tcra)Rsky mutation (0 available); any Tcra mutation (101 available)
Tcratm1Mom mutation (6 available); any Tcra mutation (101 available)
Tg(Tcrb)93Vbo mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:131357 )
• thymocyte numbers are reduced by about 3-fold
abnormal T cell differentiation ( J:131357 )
• the presence of HY TCR alleviates the beta-selection block in Ptcratm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

hematopoietic system
decreased thymocyte number ( J:131357 )
• thymocyte numbers are reduced by about 3-fold
abnormal T cell differentiation ( J:131357 )
• the presence of HY TCR alleviates the beta-selection block in Ptcratm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

endocrine/exocrine glands
decreased thymocyte number ( J:131357 )
• thymocyte numbers are reduced by about 3-fold




Genotype
MGI:3807288
cx5
Allelic
Composition		 Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
H2d/H2d
Ptcratm1Vbo/Ptcratm1Vbo
Tg(Tcrb)93Vbo/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2d mutation (23 available); any H2 mutation (282 available)
Ptcratm1Vbo mutation (0 available); any Ptcra mutation (16 available)
Tcra/Tcrdtm1.1(Tcra)Rsky mutation (0 available); any Tcrd mutation (16 available)
Tcratm1Mom mutation (6 available); any Tcra mutation (101 available)
Tg(Tcrb)93Vbo mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte number ( J:131357 )
• thymocyte numbers are reduced by about 3-fold
abnormal T cell differentiation ( J:131357 )
• the presence of HY TCR alleviates the beta-selection block in Ptcratm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

immune system
decreased thymocyte number ( J:131357 )
• thymocyte numbers are reduced by about 3-fold
abnormal T cell differentiation ( J:131357 )
• the presence of HY TCR alleviates the beta-selection block in Ptcratm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

endocrine/exocrine glands
decreased thymocyte number ( J:131357 )
• thymocyte numbers are reduced by about 3-fold




Genotype
MGI:3807289
cx6
Allelic
Composition		 H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (30 available); any H2 mutation (282 available)
Ptcratm1Vbo mutation (0 available); any Ptcra mutation (16 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:131357 )
• the presence of HY TCR alleviates the beta-selection block of developing T cells found in Ptcratm1Vbo homozygotes resulting in higher T cell numbers being found in the thymus and the spleen
• the presence of the selecting H2d allele contributes to the rescue of T cell development by the HY-TCR
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

hematopoietic system
abnormal T cell differentiation ( J:131357 )
• the presence of HY TCR alleviates the beta-selection block of developing T cells found in Ptcratm1Vbo homozygotes resulting in higher T cell numbers being found in the thymus and the spleen
• the presence of the selecting H2d allele contributes to the rescue of T cell development by the HY-TCR
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low




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11/12/2024
MGI 6.24 		The Jackson Laboratory