About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Or8a1tm25Mom
targeted mutation 25, Peter Mombaerts
MGI:3051335
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Or8a1tm4Mom/Or8a1tm25Mom involves: 129P2/OlaHsd * C57BL/6 MGI:3694193
ht2
 		Or8a1tm5Mom/Or8a1tm25Mom involves: 129P2/OlaHsd * C57BL/6 MGI:3694194
ht3
 		Or8a1tm6Mom/Or8a1tm25Mom involves: 129P2/OlaHsd * C57BL/6 MGI:3694195
ht4
 		Or8a1tm7Mom/Or8a1tm25Mom involves: 129P2/OlaHsd * C57BL/6 MGI:3694196
ht5
 		Or8a1tm8Mom/Or8a1tm25Mom involves: 129P2/OlaHsd * C57BL/6 MGI:3694197
ht6
 		Or8a1tm9Mom/Or8a1tm25Mom involves: 129P2/OlaHsd * C57BL/6 MGI:3694198
ht7
 		Or8a1tm10Mom/Or8a1tm25Mom involves: 129P2/OlaHsd * C57BL/6 MGI:3694132
cx8
 		Or8a1tm25Mom/Or8a1+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-APPSwInd)Dbo/0 		involves: 129 * C3H/HeJ * C57BL/6J MGI:5811882
cx9
 		Or8a1tm25Mom/?
Or8a1btm6Mom/?
Pcdhatm3Tyag/Pcdhatm3Tyag 		involves: 129P2/OlaHsd * C57BL/6 MGI:3799116
cx10
 		Or8a1tm25Mom/?
Pcdhatm3Tyag/Pcdhatm3Tyag 		involves: C57BL/6 MGI:3799114


Genotype
MGI:3694193
ht1
Allelic
Composition		 Or8a1tm4Mom/Or8a1tm25Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm25Mom mutation (6 available); any Or8a1 mutation (69 available)
Or8a1tm4Mom mutation (1 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory neuron innervation pattern ( J:90716 )
• Hyb D axons co-converge and co-mingle with Olfrtm25Mom axons




Genotype
MGI:3694194
ht2
Allelic
Composition		 Or8a1tm5Mom/Or8a1tm25Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm25Mom mutation (6 available); any Or8a1 mutation (69 available)
Or8a1tm5Mom mutation (0 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory neuron innervation pattern ( J:90716 )
• Hyb E axons co-converge and co-mingle with Olfrtm25Mom axons




Genotype
MGI:3694195
ht3
Allelic
Composition		 Or8a1tm6Mom/Or8a1tm25Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm25Mom mutation (6 available); any Or8a1 mutation (69 available)
Or8a1tm6Mom mutation (1 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory neuron innervation pattern ( J:90716 )
• Hyb D axons co-converge and co-mingle with Olfrtm25Mom axons




Genotype
MGI:3694196
ht4
Allelic
Composition		 Or8a1tm7Mom/Or8a1tm25Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm25Mom mutation (6 available); any Or8a1 mutation (69 available)
Or8a1tm7Mom mutation (1 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory neuron innervation pattern ( J:90716 )
• Hyb G axons co-converge and co-mingle with Olfrtm25Mom axons




Genotype
MGI:3694197
ht5
Allelic
Composition		 Or8a1tm8Mom/Or8a1tm25Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm25Mom mutation (6 available); any Or8a1 mutation (69 available)
Or8a1tm8Mom mutation (1 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory neuron innervation pattern ( J:90716 )
• Hyb H axons co-converge and co-mingle with Olfrtm25Mom axons




Genotype
MGI:3694198
ht6
Allelic
Composition		 Or8a1tm9Mom/Or8a1tm25Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm25Mom mutation (6 available); any Or8a1 mutation (69 available)
Or8a1tm9Mom mutation (1 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory neuron innervation pattern ( J:90716 )
• Hyb I axons co-converge and co-mingle with Olfrtm25Mom axons




Genotype
MGI:3694132
ht7
Allelic
Composition		 Or8a1tm10Mom/Or8a1tm25Mom
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm10Mom mutation (1 available); any Or8a1 mutation (69 available)
Or8a1tm25Mom mutation (6 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:90716 )
• Hyb J axons form distinct glomeruli that are not Olfr151 or Olfr160 in character




Genotype
MGI:5811882
cx8
Allelic
Composition		 Or8a1tm25Mom/Or8a1+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-APPSwInd)Dbo/0
Genetic
Background		 involves: 129 * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Or8a1tm25Mom mutation (6 available); any Or8a1 mutation (69 available)
Tg(tetO-APPSwInd)Dbo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
decreased olfactory sensory neuron number ( J:199798 )
• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

growth/size/body
decreased olfactory sensory neuron number ( J:199798 )
• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

nervous system
decreased olfactory sensory neuron number ( J:199798 )
• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

respiratory system
decreased olfactory sensory neuron number ( J:199798 )
• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

taste/olfaction
decreased olfactory sensory neuron number ( J:199798 )
• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli




Genotype
MGI:3799116
cx9
Allelic
Composition		 Or8a1tm25Mom/?
Or8a1btm6Mom/?
Pcdhatm3Tyag/Pcdhatm3Tyag
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1btm6Mom mutation (4 available); any Or8a1b mutation (35 available)
Or8a1tm25Mom mutation (6 available); any Or8a1 mutation (69 available)
Pcdhatm3Tyag mutation (8 available); any Pcdha mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:136920 )
• labeled axons form multiple glomeruli but none of the olfactory sensory neurons express both GFP and lacZ indicating olfactory receptor gene choice is not perturbed




Genotype
MGI:3799114
cx10
Allelic
Composition		 Or8a1tm25Mom/?
Pcdhatm3Tyag/Pcdhatm3Tyag
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm25Mom mutation (6 available); any Or8a1 mutation (69 available)
Pcdhatm3Tyag mutation (8 available); any Pcdha mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:136920 )
• more, small glomeruli are present
abnormal olfactory bulb development ( J:136920 )
• at P7, coalescence of M71 axons into glomeruli is disturbed with the average number of labeled glomeruli increased to 5.4 and 3.0 in the lateral and medial half-bulbs, respectively compared to 1.0 and 1.3 in heterozygous and wild-type controls
• several of these glomeruli appear smaller than in controls
• at P30, almost all mice still show more than 3 glomeruli per half-bulb and fewer glomeruli appear homogeneous
• at P60 multiple small glomeruli persist




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory