Analysis Tools
nervous system
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• Hyb D axons co-converge and co-mingle with Olfrtm25Mom axons
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Allele Symbol Allele Name Allele ID |
Or8a1tm25Mom targeted mutation 25, Peter Mombaerts MGI:3051335 |
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| Summary |
10 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Hyb D axons co-converge and co-mingle with Olfrtm25Mom axons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Hyb E axons co-converge and co-mingle with Olfrtm25Mom axons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Hyb D axons co-converge and co-mingle with Olfrtm25Mom axons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Hyb G axons co-converge and co-mingle with Olfrtm25Mom axons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Hyb H axons co-converge and co-mingle with Olfrtm25Mom axons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Hyb I axons co-converge and co-mingle with Olfrtm25Mom axons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Hyb J axons form distinct glomeruli that are not Olfr151 or Olfr160 in character
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli
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• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli
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• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli
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• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli
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• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• labeled axons form multiple glomeruli but none of the olfactory sensory neurons express both GFP and lacZ indicating olfactory receptor gene choice is not perturbed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• more, small glomeruli are present
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• at P7, coalescence of M71 axons into glomeruli is disturbed with the average number of labeled glomeruli increased to 5.4 and 3.0 in the lateral and medial half-bulbs, respectively compared to 1.0 and 1.3 in heterozygous and wild-type controls
• several of these glomeruli appear smaller than in controls
• at P30, almost all mice still show more than 3 glomeruli per half-bulb and fewer glomeruli appear homogeneous
• at P60 multiple small glomeruli persist
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/03/2024 MGI 6.24 |
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