Analysis Tools|
Allele Symbol Allele Name Allele ID |
Or8a1tm26Mom targeted mutation 26, Peter Mombaerts MGI:3051336 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• glomeruli in heterozygotes containing the C57BL/6 pseudogene are reduced from ~50 um diameter to ~32 um in diameter
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• there is ~50% reduction of axonal inputs innervating glomeruli; all axons are of Olfr151
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Hyb C axons co-converge and co-mingle with Olfr151-GFP axons in the glomeruli
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• atypical glomeruli are formed in which some co-mingling of Olfr151tm2Momaxons with both Olfr151 and Olfr160 axons occurs, but Olfr151tm2Momaxons are shared between glomeruli
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• Hyb A axons co-converge and co-mingle with Olfr151-GFP axons in the glomeruli
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• olfactory sensory neuron axons form ectopic, ventral glomeruli in the olfactory bulb either with or without the presence of glomeruli in the expected position
• when only ectopic glomeruli are present both red and green axons are present; however when two pairs of glomeruli are present the ectopic glomeruli contain primarily red axons
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
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• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
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• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
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• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
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• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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