nervous system
• an additional lacZ positive glomerulus is detected on the dorsolateral side of the olfactory bulb, only the glomerulus on the medial side is detected in controls
|
Allele Symbol Allele Name Allele ID |
Or8a1btm4Mom targeted mutation 4, Peter Mombaerts MGI:3051343 |
||||||||||||||||||||||||||||||||||||
Summary |
8 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• an additional lacZ positive glomerulus is detected on the dorsolateral side of the olfactory bulb, only the glomerulus on the medial side is detected in controls
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• decrease in the number of labeled sensory neurons in the olfactory bulb
|
• some labeled axons innervate aberrant extra glomeruli in the olfactory bulb
|
• decrease in the number of labeled sensory neurons in the olfactory bulb
|
• decrease in the number of labeled sensory neurons in the olfactory bulb
|
• decrease in the number of labeled sensory neurons in the olfactory bulb
|
• decrease in the number of labeled sensory neurons in the olfactory bulb
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
Olfactory sensory neurons axon targeting is perturbed in Ttc8tm1Reed/Ttc8tm1Reed Or8a1btm4Mom/Or8a1b+ mice
• impaired fasiculation of olfactory sensory neuron axons
|
• unlike in controls where all labeled axons converge to a single, posterior glomerulus, multiple glomeruli are innervated by olfactory sensory neuron axons and individual "wandering" fibers are observed
|
• impaired fasiculation of olfactory sensory neuron axons
|
• unlike in controls where all labeled axons converge to a single, posterior glomerulus, multiple glomeruli are innervated by olfactory sensory neuron axons and individual "wandering" fibers are observed
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
|
• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
|
• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
|
• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
|
• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• glomeruli structure is irregular
|
• on the median and lateral sides of the bulb, fewer Olfr160+ neurons form large glomeruli as in wild-type mice
• fewer Olfr160+ neurons are present (197+/-40 compared to 213+/-51 in wild-type mice)
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• Hyb J axons form distinct glomeruli that are not Olfr151 or Olfr160 in character
|
• Hyb J axons form distinct glomeruli that are not Olfr151 or Olfr160 in character
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
|
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• Olfr160+ glomeruli are localized more ventrally than in wild-type mice
• at day 7, extra minor glomeruli are observed
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or to continue to grow past the glomerulus layer into the deep layers of the bulb
|
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
|
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
|
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
|
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
|
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• Olfr160+ glomeruli are localized more ventrally than in wild-type mice
• at day 7, extra minor glomeruli are observed
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or to continue to grow past the glomerulus layer into the deep layers of the bulb
|
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
|
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
|
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
|
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 08/02/2024 MGI 6.24 |
![]() |
|