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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Or8a1btm4Mom
targeted mutation 4, Peter Mombaerts
MGI:3051343
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Robo2tm1Rilm/Robo2tm1Rilm
Or8a1btm4Mom/?
Omptm1(cre)Jae/Omp+ 		involves: 129 * 129P2/OlaHsd * 129S1/Sv MGI:5449874
cx2
 		Ebf2tm3.1(Zfp423*)Reed/Ebf2+
Or8a1btm4Mom/Or8a1b+ 		involves: 129 * 129P2/OlaHsd * C57BL/10J MGI:5461571
cx3
 		Or8a1btm4Mom/Or8a1b+
Ttc8tm1Reed/Ttc8tm1Reed 		involves: 129 * 129P2/OlaHsd * C57BL/6 MGI:5140727
cx4
 		Ebf2tm1Reed/Ebf2+
Or8a1btm4Mom/Or8a1b+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:3714645
cx5
 		Adcy3tm1Drs/Adcy3tm1Drs
Or8a1btm4Mom/Or8a1b+ 		involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 MGI:3714866
cx6
 		Or8a1tm10Mom/Or8a1+
Or8a1btm4Mom/Or8a1b+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3694133
cx7
 		Cnga2tm1Mom/Y
Or8a1btm4Mom/Or8a1b+ 		involves: 129P2/OlaHsd * C57BL/6J MGI:3718349
cx8
 		Cnga2tm1Mom/Cnga2tm1Mom
Or8a1btm4Mom/Or8a1b+ 		involves: 129P2/OlaHsd * C57BL/6J MGI:3718347


Genotype
MGI:5449874
cn1
Allelic
Composition		 Robo2tm1Rilm/Robo2tm1Rilm
Or8a1btm4Mom/?
Omptm1(cre)Jae/Omp+
Genetic
Background		 involves: 129 * 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(cre)Jae mutation (0 available); any Omp mutation (27 available)
Or8a1btm4Mom mutation (1 available); any Or8a1b mutation (35 available)
Robo2tm1Rilm mutation (1 available); any Robo2 mutation (101 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:173325 )
• an additional lacZ positive glomerulus is detected on the dorsolateral side of the olfactory bulb, only the glomerulus on the medial side is detected in controls




Genotype
MGI:5461571
cx2
Allelic
Composition		 Ebf2tm3.1(Zfp423*)Reed/Ebf2+
Or8a1btm4Mom/Or8a1b+
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/10J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2tm3.1(Zfp423*)Reed mutation (0 available); any Ebf2 mutation (30 available)
Or8a1btm4Mom mutation (1 available); any Or8a1b mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory sensory neuron morphology ( J:190934 )
• decrease in the number of labeled sensory neurons in the olfactory bulb
abnormal sensory neuron innervation pattern ( J:190934 )
• some labeled axons innervate aberrant extra glomeruli in the olfactory bulb

craniofacial
abnormal olfactory sensory neuron morphology ( J:190934 )
• decrease in the number of labeled sensory neurons in the olfactory bulb

respiratory system
abnormal olfactory sensory neuron morphology ( J:190934 )
• decrease in the number of labeled sensory neurons in the olfactory bulb

taste/olfaction
abnormal olfactory sensory neuron morphology ( J:190934 )
• decrease in the number of labeled sensory neurons in the olfactory bulb

growth/size/body
abnormal olfactory sensory neuron morphology ( J:190934 )
• decrease in the number of labeled sensory neurons in the olfactory bulb




Genotype
MGI:5140727
cx3
Allelic
Composition		 Or8a1btm4Mom/Or8a1b+
Ttc8tm1Reed/Ttc8tm1Reed
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1btm4Mom mutation (1 available); any Or8a1b mutation (35 available)
Ttc8tm1Reed mutation (0 available); any Ttc8 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Olfactory sensory neurons axon targeting is perturbed in Ttc8tm1Reed/Ttc8tm1Reed Or8a1btm4Mom/Or8a1b+ mice

nervous system
abnormal axon fasciculation ( J:173465 )
• impaired fasiculation of olfactory sensory neuron axons
abnormal axon guidance ( J:173465 )
• unlike in controls where all labeled axons converge to a single, posterior glomerulus, multiple glomeruli are innervated by olfactory sensory neuron axons and individual "wandering" fibers are observed

cellular
abnormal axon fasciculation ( J:173465 )
• impaired fasiculation of olfactory sensory neuron axons
abnormal axon guidance ( J:173465 )
• unlike in controls where all labeled axons converge to a single, posterior glomerulus, multiple glomeruli are innervated by olfactory sensory neuron axons and individual "wandering" fibers are observed




Genotype
MGI:3714645
cx4
Allelic
Composition		 Ebf2tm1Reed/Ebf2+
Or8a1btm4Mom/Or8a1b+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2tm1Reed mutation (0 available); any Ebf2 mutation (30 available)
Or8a1btm4Mom mutation (1 available); any Or8a1b mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory sensory neuron morphology ( J:122275 )
• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

craniofacial
abnormal olfactory sensory neuron morphology ( J:122275 )
• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

respiratory system
abnormal olfactory sensory neuron morphology ( J:122275 )
• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

taste/olfaction
abnormal olfactory sensory neuron morphology ( J:122275 )
• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

growth/size/body
abnormal olfactory sensory neuron morphology ( J:122275 )
• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb




Genotype
MGI:3714866
cx5
Allelic
Composition		 Adcy3tm1Drs/Adcy3tm1Drs
Or8a1btm4Mom/Or8a1b+
Genetic
Background		 involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy3tm1Drs mutation (0 available); any Adcy3 mutation (43 available)
Or8a1btm4Mom mutation (1 available); any Or8a1b mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:122528 )
• glomeruli structure is irregular
abnormal olfactory nerve morphology ( J:122528 )
• on the median and lateral sides of the bulb, fewer Olfr160+ neurons form large glomeruli as in wild-type mice
• fewer Olfr160+ neurons are present (197+/-40 compared to 213+/-51 in wild-type mice)




Genotype
MGI:3694133
cx6
Allelic
Composition		 Or8a1tm10Mom/Or8a1+
Or8a1btm4Mom/Or8a1b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1btm4Mom mutation (1 available); any Or8a1b mutation (35 available)
Or8a1tm10Mom mutation (1 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:90716 )
• Hyb J axons form distinct glomeruli that are not Olfr151 or Olfr160 in character
abnormal olfactory neuron innervation pattern ( J:90716 )
• Hyb J axons form distinct glomeruli that are not Olfr151 or Olfr160 in character




Genotype
MGI:3718349
cx7
Allelic
Composition		 Cnga2tm1Mom/Y
Or8a1btm4Mom/Or8a1b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Mom mutation (2 available); any Cnga2 mutation (17 available)
Or8a1btm4Mom mutation (1 available); any Or8a1b mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
abnormal olfactory bulb morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• Olfr160+ glomeruli are localized more ventrally than in wild-type mice
• at day 7, extra minor glomeruli are observed
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or to continue to grow past the glomerulus layer into the deep layers of the bulb

craniofacial
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb

respiratory system
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb

taste/olfaction
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb

growth/size/body
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb




Genotype
MGI:3718347
cx8
Allelic
Composition		 Cnga2tm1Mom/Cnga2tm1Mom
Or8a1btm4Mom/Or8a1b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Mom mutation (2 available); any Cnga2 mutation (17 available)
Or8a1btm4Mom mutation (1 available); any Or8a1b mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
abnormal olfactory bulb morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• Olfr160+ glomeruli are localized more ventrally than in wild-type mice
• at day 7, extra minor glomeruli are observed
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or to continue to grow past the glomerulus layer into the deep layers of the bulb

craniofacial
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb

respiratory system
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb

taste/olfaction
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb

growth/size/body
abnormal olfactory sensory neuron morphology ( J:67661 )
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb




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Send questions and comments to User Support. 		last database update
12/17/2024
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