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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxd11tm2Ddu
targeted mutation 2, Denis Duboule
MGI:3051381
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hoxd11tm2Ddu/Hoxd11tm2Ddu involves: 129S2/SvPas * C57BL/6J MGI:3718229
ht2
 		Hoxd11tm2Ddu/Hoxd11+ involves: 129S2/SvPas * C57BL/6J MGI:3718240
ht3
 		Hoxd11tm1Ipc/Hoxd11tm2Ddu involves: 129S2/SvPas * C57BL/6J MGI:3718239


Genotype
MGI:3718229
hm1
Allelic
Composition		 Hoxd11tm2Ddu/Hoxd11tm2Ddu
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd11tm2Ddu mutation (0 available); any Hoxd11 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal carpal bone morphology ( J:41828 )
• 22 of 22 mice have carpal bone defects
• cartilage and ossification centers between the pyramidal and navicular-lunate are fused
abnormal lumbar vertebrae morphology ( J:41828 )
• 17 of 22 mice have an abnormal L4
• 7 of 22 mice have an abnormal L6
increased lumbar vertebrae number ( J:41828 )
• 11 of 22 mice showed an L7 formula

limbs/digits/tail
abnormal carpal bone morphology ( J:41828 )
• 22 of 22 mice have carpal bone defects
• cartilage and ossification centers between the pyramidal and navicular-lunate are fused




Genotype
MGI:3718240
ht2
Allelic
Composition		 Hoxd11tm2Ddu/Hoxd11+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd11tm2Ddu mutation (0 available); any Hoxd11 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal lumbar vertebrae morphology ( J:41828 )
• 10 of 34 mice have an abnormal L4




Genotype
MGI:3718239
ht3
Allelic
Composition		 Hoxd11tm1Ipc/Hoxd11tm2Ddu
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd11tm1Ipc mutation (0 available); any Hoxd11 mutation (14 available)
Hoxd11tm2Ddu mutation (0 available); any Hoxd11 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal carpal bone morphology ( J:41828 )
• 7 of 7 mice have carpal bone defects
• cartilage and ossification centers between the pyramidal and navicular-lunate are partially fused
abnormal lumbar vertebrae morphology ( J:41828 )
• 3 of 7 mice have an abnormal L6
increased lumbar vertebrae number ( J:41828 )
• 2 of 7 mice showed an L7 formula instead of an L6 formula found in wild-type mice

limbs/digits/tail
abnormal carpal bone morphology ( J:41828 )
• 7 of 7 mice have carpal bone defects
• cartilage and ossification centers between the pyramidal and navicular-lunate are partially fused




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory