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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hoxd11tm2.1Ddu
targeted mutation 2.1, Denis Duboule
MGI:3051383
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Hoxd11tm2.1Ddu/Hoxd11tm2.1Ddu involves: 129S2/SvPas * C57BL/6J MGI:3718227
cx2
 		Hoxa11tm1Ssp/Hoxa11+
Hoxd11tm2.1Ddu/Hoxd11tm2.1Ddu 		involves: 129S2/SvPas * C57BL/6J MGI:3718231
cx3
 		Hoxa11tm1Ssp/Hoxa11tm1Ssp
Hoxd11tm2.1Ddu/Hoxd11tm2.1Ddu 		involves: 129S2/SvPas * C57BL/6J MGI:3718233
cx4
 		Hoxa11tm1Ssp/Hoxa11tm1Ssp
Hoxd11tm2.1Ddu/Hoxd11+ 		involves: 129S2/SvPas * C57BL/6J MGI:3718234
cx5
 		Del(2Hoxd11-Hoxd13)29Ddu/Del(2Hoxd11-Hoxd13)29Ddu
Hoxd11tm2.1Ddu/Hoxd11tm2.1Ddu 		involves: 129S2/SvPas * C57BL/6J MGI:3718235
cx6
 		Hoxa11tm1Ssp/Hoxa11+
Hoxd11tm2.1Ddu/Hoxd11+ 		involves: 129S2/SvPas * C57BL/6J MGI:3718236


Genotype
MGI:3718227
hm1
Allelic
Composition		 Hoxd11tm2.1Ddu/Hoxd11tm2.1Ddu
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd11tm2.1Ddu mutation (0 available); any Hoxd11 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal lumbar vertebrae morphology ( J:41828 )
• 14 of 19 mice have an abnormal L4
• 14 of 19 mice have an abnormal L6
increased lumbar vertebrae number ( J:41828 )
• 2 of 19 mice showed an L7 formula instead of an L6 formula found in wild-type mice
abnormal sacral vertebrae morphology ( J:41828 )
• sacrum starts one vertebrae more posterior than in wild-type mice
sacral vertebral transformation ( J:41828 )
• S1 is partially transformed into a lumbar vertebrae




Genotype
MGI:3718231
cx2
Allelic
Composition		 Hoxa11tm1Ssp/Hoxa11+
Hoxd11tm2.1Ddu/Hoxd11tm2.1Ddu
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11tm1Ssp mutation (0 available); any Hoxa11 mutation (11 available)
Hoxd11tm2.1Ddu mutation (0 available); any Hoxd11 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal lumbar vertebrae morphology ( J:41828 )
• 11 of 11 mice have abnormal L4
• 4 of 11 mice have abnormal L6
increased lumbar vertebrae number ( J:41828 )
• 7 of 11 mice have an L7 formula instead of an L6 formula found in wild-type mice




Genotype
MGI:3718233
cx3
Allelic
Composition		 Hoxa11tm1Ssp/Hoxa11tm1Ssp
Hoxd11tm2.1Ddu/Hoxd11tm2.1Ddu
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11tm1Ssp mutation (0 available); any Hoxa11 mutation (11 available)
Hoxd11tm2.1Ddu mutation (0 available); any Hoxd11 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal carpal bone morphology ( J:41828 )
• 2 of 2 mice have carpal bone defects
fused carpal bones ( J:41828 )
• pisiform and pyramidal bones are fused and attached to the navicular-lunate
abnormal radius morphology ( J:41828 )
• radius and ulna are abnormally broad
abnormal ulna morphology ( J:41828 )
• radius and ulna are abnormally broad
abnormal lumbar vertebrae morphology ( J:41828 )
• 2 of 2 mice have abnormal L4
increased lumbar vertebrae number ( J:41828 )
• 2 of 2 mice have an L7 formula instead of an L6 formula found in wild-type mice

limbs/digits/tail
abnormal carpal bone morphology ( J:41828 )
• 2 of 2 mice have carpal bone defects
fused carpal bones ( J:41828 )
• pisiform and pyramidal bones are fused and attached to the navicular-lunate
abnormal radius morphology ( J:41828 )
• radius and ulna are abnormally broad
abnormal ulna morphology ( J:41828 )
• radius and ulna are abnormally broad




Genotype
MGI:3718234
cx4
Allelic
Composition		 Hoxa11tm1Ssp/Hoxa11tm1Ssp
Hoxd11tm2.1Ddu/Hoxd11+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11tm1Ssp mutation (0 available); any Hoxa11 mutation (11 available)
Hoxd11tm2.1Ddu mutation (0 available); any Hoxd11 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal carpal bone morphology ( J:41828 )
• 4 of 7 mice have carpal bone defects
abnormal lumbar vertebrae morphology ( J:41828 )
• 6 of 7 mice have abnormal L4
increased lumbar vertebrae number ( J:41828 )
• 6 of 7 mice have an L7 formula instead of an L6 formula found in wild

limbs/digits/tail
abnormal carpal bone morphology ( J:41828 )
• 4 of 7 mice have carpal bone defects




Genotype
MGI:3718235
cx5
Allelic
Composition		 Del(2Hoxd11-Hoxd13)29Ddu/Del(2Hoxd11-Hoxd13)29Ddu
Hoxd11tm2.1Ddu/Hoxd11tm2.1Ddu
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)29Ddu mutation (2 available); any Del(2Hoxd11-Hoxd13)29Ddu mutation (2 available)
Hoxd11tm2.1Ddu mutation (0 available); any Hoxd11 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal phalanx morphology ( J:41828 )
• second phalanges of digits II and V are reduced in size
abnormal lumbar vertebrae morphology ( J:41828 )
• 5 of 5 mice have abnormal L4
• 2 of 5 mice have abnormal L6
increased lumbar vertebrae number ( J:41828 )
• 3 of 5 mice have an L7 formula instead of an L6 formula found in wild-type mice

limbs/digits/tail
abnormal phalanx morphology ( J:41828 )
• second phalanges of digits II and V are reduced in size




Genotype
MGI:3718236
cx6
Allelic
Composition		 Hoxa11tm1Ssp/Hoxa11+
Hoxd11tm2.1Ddu/Hoxd11+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa11tm1Ssp mutation (0 available); any Hoxa11 mutation (11 available)
Hoxd11tm2.1Ddu mutation (0 available); any Hoxd11 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal carpal bone morphology ( J:41828 )
• 1 of 11 mice have carpal bone defects
abnormal lumbar vertebrae morphology ( J:41828 )
• 7 of 11 mice have abnormal L4
• 1 of 11 mice have abnormal L6
increased lumbar vertebrae number ( J:41828 )
• 2 of 11 mice have an L7 formula instead of an L6 formula found in wild-type mice

limbs/digits/tail
abnormal carpal bone morphology ( J:41828 )
• 1 of 11 mice have carpal bone defects




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory