immune system
• mutants are more resistant to LPS induced endotoxin shock
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Allele Symbol Allele Name Allele ID |
Socs3tm1Ayos targeted mutation 1, Akihiko Yoshimura MGI:3051525 |
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Summary |
3 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mutants are more resistant to LPS induced endotoxin shock
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• on a high fat diet total fat weight and individual fat pad weights increase less in mutants compared to wild-type mice
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• food intake is decreased on a high fat diet compared to wild-type mice on the same diet
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• on a high fat diet total fat weight and individual fat pad weights increase less in mutants compared to wild-type mice
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• on a high fat diet mutants gain less weight
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• after 22 weeks on a high fat diet plasma free fatty acid levels are significantly lower in mutants
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• after 22 weeks on a high fat diet triglyceride levels are significantly lower in mutants
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• glucose clearance is significantly faster in mutants compared to wild-type mice
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• on a high fat diet mutants do not develop insulin resistance
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• leptin treatment induces a greater decrease in food intake in mutants compared to wild-type mice
• treatment with leptin induces greater weight loss in mutants
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• on a high fat diet total fat weight and individual fat pad weights increase less in mutants compared to wild-type mice
|
• food intake is decreased on a high fat diet compared to wild-type mice on the same diet
|
• on a high fat diet total fat weight and individual fat pad weights increase less in mutants compared to wild-type mice
|
• on a high fat diet mutants gain less weight
|
• after 22 weeks on a high fat diet plasma free fatty acid levels are significantly lower in mutants
|
• after 22 weeks on a high fat diet triglyceride levels are significantly lower in mutants
|
• glucose clearance is significantly faster in mutants compared to wild-type mice
|
• on a high fat diet mutants do not develop insulin resistance
|
• leptin treatment induces a greater decrease in food intake in mutants compared to wild-type mice
• treatment with leptin induces greater weight loss in mutants
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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