Phenotypes associated with this allele

• Allele Symbol: Socs3^tm1Ayos
• Allele Name: targeted mutation 1, Akihiko Yoshimura
• Allele ID: MGI:3051525
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Socs3^tm1Ayos/Socs3^tm1Ayos Lyz2^tm1(cre)Ifo/Lyz2^+	involves: 129 * C57BL/6	MGI:3051636
cn2	Socs3^tm1Ayos/Socs3^tm1Ayos Tg(Nes-cre)1Kln/0	involves: 129 * C57BL/6	MGI:3051638
cn3	Socs3^tm1Ayos/Socs3^tm1Ayos Tg(Syn1-cre)671Jxm/0	involves: 129 * C57BL/6	MGI:3051642

Genotype
MGI:3051636

cn1

• Allelic Composition: Socs3^tm1Ayos/Socs3^tm1Ayos; Lyz2^tm1(cre)Ifo/Lyz2⁺
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to endotoxin shock ( J:92040 )

• mutants are more resistant to LPS induced endotoxin shock

Genotype
MGI:3051638

cn2

• Allelic Composition: Socs3^tm1Ayos/Socs3^tm1Ayos; Tg(Nes-cre)1Kln/0
• Genetic Background: involves: 129 * C57BL/6

adipose tissue

decreased body fat mass ( J:91796 )

• on a high fat diet total fat weight and individual fat pad weights increase less in mutants compared to wild-type mice

behavior/neurological

abnormal food intake ( J:91796 )

• food intake is decreased on a high fat diet compared to wild-type mice on the same diet

growth/size/body

decreased body fat mass ( J:91796 )

• on a high fat diet total fat weight and individual fat pad weights increase less in mutants compared to wild-type mice

decreased body weight ( J:91796 )

• on a high fat diet mutants gain less weight

homeostasis/metabolism

decreased circulating free fatty acids level ( J:91796 )

• after 22 weeks on a high fat diet plasma free fatty acid levels are significantly lower in mutants

decreased circulating triglyceride level ( J:91796 )

• after 22 weeks on a high fat diet triglyceride levels are significantly lower in mutants

improved glucose tolerance ( J:91796 )

• glucose clearance is significantly faster in mutants compared to wild-type mice

increased insulin sensitivity ( J:91796 )

• on a high fat diet mutants do not develop insulin resistance

increased response to leptin ( J:91796 )

• leptin treatment induces a greater decrease in food intake in mutants compared to wild-type mice

• treatment with leptin induces greater weight loss in mutants

Genotype
MGI:3051642

cn3

• Allelic Composition: Socs3^tm1Ayos/Socs3^tm1Ayos; Tg(Syn1-cre)671Jxm/0
• Genetic Background: involves: 129 * C57BL/6

adipose tissue

decreased body fat mass ( J:91796 )

• on a high fat diet total fat weight and individual fat pad weights increase less in mutants compared to wild-type mice

behavior/neurological

abnormal food intake ( J:91796 )

• food intake is decreased on a high fat diet compared to wild-type mice on the same diet

growth/size/body

decreased body fat mass ( J:91796 )

• on a high fat diet total fat weight and individual fat pad weights increase less in mutants compared to wild-type mice

decreased body weight ( J:91796 )

• on a high fat diet mutants gain less weight

homeostasis/metabolism

decreased circulating free fatty acids level ( J:91796 )

• after 22 weeks on a high fat diet plasma free fatty acid levels are significantly lower in mutants

decreased circulating triglyceride level ( J:91796 )

• after 22 weeks on a high fat diet triglyceride levels are significantly lower in mutants

improved glucose tolerance ( J:91796 )

• glucose clearance is significantly faster in mutants compared to wild-type mice

increased insulin sensitivity ( J:91796 )

• on a high fat diet mutants do not develop insulin resistance

increased response to leptin ( J:91796 )

• leptin treatment induces a greater decrease in food intake in mutants compared to wild-type mice

• treatment with leptin induces greater weight loss in mutants