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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atp2b1tm1Ges
targeted mutation 1, Gary E Shull
MGI:3051541
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Atp2b1tm1Ges/Atp2b1tm1Ges involves: 129X1/SvJ * Black Swiss MGI:3051592
cx2
 		Atp2b1tm1Ges/Atp2b1+
Atp2b4tm1Ges/Atp2b4tm1Ges 		Black Swiss MGI:3051593


Genotype
MGI:3051592
hm1
Allelic
Composition		 Atp2b1tm1Ges/Atp2b1tm1Ges
Genetic
Background		 involves: 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b1tm1Ges mutation (1 available); any Atp2b1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:91844 )
• no live homozygous pups are found




Genotype
MGI:3051593
cx2
Allelic
Composition		 Atp2b1tm1Ges/Atp2b1+
Atp2b4tm1Ges/Atp2b4tm1Ges
Genetic
Background		 Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b1tm1Ges mutation (1 available); any Atp2b1 mutation (66 available)
Atp2b4tm1Ges mutation (1 available); any Atp2b4 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
decreased vasoconstriction ( J:91844 )
• portal vein contractility is reduced and increased apoptosis is seen smooth muscle cells surrounding the portal vein after 4 hours in culture compared to wild-type mice
• Background Sensitivity: this phenotype is not as severe as for Atp2b4tm1Ges homozygotes on a mixed 129/SvJ and Black Swiss background

cardiovascular system
decreased vasoconstriction ( J:91844 )
• portal vein contractility is reduced and increased apoptosis is seen smooth muscle cells surrounding the portal vein after 4 hours in culture compared to wild-type mice
• Background Sensitivity: this phenotype is not as severe as for Atp2b4tm1Ges homozygotes on a mixed 129/SvJ and Black Swiss background




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory