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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atp2b4tm1Ges
targeted mutation 1, Gary E Shull
MGI:3051542
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Atp2b4tm1Ges/Atp2b4tm1Ges BKSW.129X1-Atp2b4tm1Ges MGI:3051595
hm2
 		Atp2b4tm1Ges/Atp2b4tm1Ges involves: 129X1/SvJ * Black Swiss MGI:3051594
cx3
 		Atp2b1tm1Ges/Atp2b1+
Atp2b4tm1Ges/Atp2b4tm1Ges 		Black Swiss MGI:3051593


Genotype
MGI:3051595
hm1
Allelic
Composition		 Atp2b4tm1Ges/Atp2b4tm1Ges
Genetic
Background		 BKSW.129X1-Atp2b4tm1Ges
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b4tm1Ges mutation (1 available); any Atp2b4 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Atp2b4tm1Ges/Atp2b4tm1Ges sperm tails exhibit an increase in the number of condensed mitochondria

reproductive system
asthenozoospermia ( J:91844 )
• hyperactivated sperm motility is severely impaired with most mutant sperm non-motile after 90 min in conditions that should result in hyperactivation
• in hyperactivating conditions mutant sperm have significantly more condensed mitochondria compared to wild-type sperm
• mutant sperm have normal motility in the epididymis
male infertility ( J:91844 )
• males but not females are infertile

cellular
asthenozoospermia ( J:91844 )
• hyperactivated sperm motility is severely impaired with most mutant sperm non-motile after 90 min in conditions that should result in hyperactivation
• in hyperactivating conditions mutant sperm have significantly more condensed mitochondria compared to wild-type sperm
• mutant sperm have normal motility in the epididymis




Genotype
MGI:3051594
hm2
Allelic
Composition		 Atp2b4tm1Ges/Atp2b4tm1Ges
Genetic
Background		 involves: 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b4tm1Ges mutation (1 available); any Atp2b4 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Atp2b4tm1Ges/Atp2b4tm1Ges portal vein smooth muscle shows an increase in apoptosis

behavior/neurological
excessive scratching ( J:91844 )
• excessive scratching is seen around the jaw and is correlated with an enlarged submandibular gland
• this phenotype is not seen on an inbred Black Swiss background

immune system
enlarged submandibular lymph nodes ( J:91844 )
• the submandibular gland is enlarged
• this phenotype is not seen on an inbred Black Swiss background

reproductive system
male infertility ( J:91844 )
• males but not females are infertile

muscle
decreased vasoconstriction ( J:91844 )
• portal vein contractility is reduced and increased apoptosis is seen smooth muscle cells surrounding the portal vein after 4 hours in culture compared to wild-type mice

cardiovascular system
decreased vasoconstriction ( J:91844 )
• portal vein contractility is reduced and increased apoptosis is seen smooth muscle cells surrounding the portal vein after 4 hours in culture compared to wild-type mice




Genotype
MGI:3051593
cx3
Allelic
Composition		 Atp2b1tm1Ges/Atp2b1+
Atp2b4tm1Ges/Atp2b4tm1Ges
Genetic
Background		 Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2b1tm1Ges mutation (1 available); any Atp2b1 mutation (66 available)
Atp2b4tm1Ges mutation (1 available); any Atp2b4 mutation (55 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
decreased vasoconstriction ( J:91844 )
• portal vein contractility is reduced and increased apoptosis is seen smooth muscle cells surrounding the portal vein after 4 hours in culture compared to wild-type mice
• Background Sensitivity: this phenotype is not as severe as for Atp2b4tm1Ges homozygotes on a mixed 129/SvJ and Black Swiss background

cardiovascular system
decreased vasoconstriction ( J:91844 )
• portal vein contractility is reduced and increased apoptosis is seen smooth muscle cells surrounding the portal vein after 4 hours in culture compared to wild-type mice
• Background Sensitivity: this phenotype is not as severe as for Atp2b4tm1Ges homozygotes on a mixed 129/SvJ and Black Swiss background




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory