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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hprt1tm1(Ggt1-Agtr1)Cof
targeted mutation 1, Thomas M Coffman
MGI:3051543
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Agtr1atm1Unc/Agtr1atm1Unc
Hprt1tm1(Ggt1-Agtr1)Cof/Y 		involves: 129P2/OlaHsd MGI:3051599
cx2
 		Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Hprt1tm1(Ggt1-Agtr1)Cof/Y 		involves: 129P2/OlaHsd MGI:3051600
ot3
 		Hprt1tm1(Ggt1-Agtr1)Cof/Y involves: 129P2/OlaHsd MGI:3051598


Genotype
MGI:3051599
cx1
Allelic
Composition		 Agtr1atm1Unc/Agtr1atm1Unc
Hprt1tm1(Ggt1-Agtr1)Cof/Y
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Hprt1tm1(Ggt1-Agtr1)Cof mutation (0 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
hypotension ( J:91837 )
• hypotension develops on low salt diet and blood pressure fails to rise on a high salt diet
• fails to correct blood pressure defect caused by homozygous Agtr1tm1Unc

homeostasis/metabolism
decreased urine osmolality ( J:91837 )
• fails to correct defect in urinary concentration caused by homozygous Agtr1tm1Unc

renal/urinary system
decreased urine osmolality ( J:91837 )
• fails to correct defect in urinary concentration caused by homozygous Agtr1tm1Unc




Genotype
MGI:3051600
cx2
Allelic
Composition		 Agtr1atm1Unc/Agtr1atm1Unc
Agtr1btm1Cof/Agtr1btm1Cof
Hprt1tm1(Ggt1-Agtr1)Cof/Y
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Agtr1atm1Unc mutation (1 available); any Agtr1a mutation (40 available)
Agtr1btm1Cof mutation (0 available); any Agtr1b mutation (18 available)
Hprt1tm1(Ggt1-Agtr1)Cof mutation (0 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased renin activity ( J:91837 )
• renin levels reduced by 70% from levels found in mice homozygous for both Agtr1tm1Unc and Agtr1btm1Cof
• renin levels essentially normal

renal/urinary system
kidney cyst ( J:91837 )
• greatly reduced number and size of glomerular and cortical cysts relative to the condition in mice homozygous for both Agtr1tm1Unc and Agtr1btm1Cof
• architecture of the renal cortex is preserved

growth/size/body
kidney cyst ( J:91837 )
• greatly reduced number and size of glomerular and cortical cysts relative to the condition in mice homozygous for both Agtr1tm1Unc and Agtr1btm1Cof
• architecture of the renal cortex is preserved




Genotype
MGI:3051598
ot3
Allelic
Composition		 Hprt1tm1(Ggt1-Agtr1)Cof/Y
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(Ggt1-Agtr1)Cof mutation (0 available); any Hprt1 mutation (1279 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory