All Phenotypes Alpl<Hpp> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Alpl^Hpp
hypophosphatasia
MGI:3051587

Summary

2 genotypes

Allelic Composition	Alpl^Hpp/Alpl^Hpp
Genetic Background	involves: BALB/cAnN * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpl^Hpp mutation (2 available); any Alpl mutation (352 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

• plasma ALP levels are very low, but detectable in 5 week old homozygotes

• ALP levels decrease further with age at a similar rate to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
adult hypophosphatasia		DOID:0110913	OMIM:146300	J:122319

Allelic Composition	Alpl^Hpp/Alpl⁺
Genetic Background	involves: BALB/cAnN * C3H/HeH

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpl^Hpp mutation (2 available); any Alpl mutation (352 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

• plasma ALP levels are less than 50% of controls at 5 weeks of age (J:122319)

• ALP levels decrease further with age at a similar rate to controls (J:122319)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
adult hypophosphatasia		DOID:0110913	OMIM:146300	J:122319

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24